8-(1-Benzenesulfonyl-1H-indol-2-yl)-9-(2-benzyloxy-ethyl)-1,5-dithia-9-aza-spiro[5.5]undecane

Base Information

• Chemical Name: 8-(1-Benzenesulfonyl-1H-indol-2-yl)-9-(2-benzyloxy-ethyl)-1,5-dithia-9-aza-spiro[5.5]undecane
• CAS No.: 178944-68-8
• Molecular Formula: C₃₁H₃₄N₂O₃S₃
• Molecular Weight: 578.821

Synonyms:8-(1-Benzenesulfonyl-1H-indol-2-yl)-9-(2-benzyloxy-ethyl)-1,5-dithia-9-aza-spiro[5.5]undecane

Chemical Property of 8-(1-Benzenesulfonyl-1H-indol-2-yl)-9-(2-benzyloxy-ethyl)-1,5-dithia-9-aza-spiro[5.5]undecane

Chemical Property:

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Technology Process of 8-(1-Benzenesulfonyl-1H-indol-2-yl)-9-(2-benzyloxy-ethyl)-1,5-dithia-9-aza-spiro[5.5]undecane

There total 6 articles about 8-(1-Benzenesulfonyl-1H-indol-2-yl)-9-(2-benzyloxy-ethyl)-1,5-dithia-9-aza-spiro[5.5]undecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

benzyl bromide (100-39-0) + 2-[8-(1-Benzenesulfonyl-1H-indol-2-yl)-1,5-dithia-9-aza-spiro[5.5]undec-9-yl]-ethanol (178944-69-9) → 8-(1-Benzenesulfonyl-1H-indol-2-yl)-9-(2-benzyloxy-ethyl)-1,5-dithia-9-aza-spiro[5.5]undecane (178944-68-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran; diethyl ether; Ambient temperature;

DOI:10.1016/0040-4020(96)00399-7

Reference yield: 41.0%

7-(1-Benzenesulfonyl-1H-indol-2-yl)-8-(2-benzyloxy-ethyl)-1,4-dioxa-8-aza-spiro[4.5]decane (178944-67-7) → 2-[8-(1-Benzenesulfonyl-1H-indol-2-yl)-1,5-dithia-9-aza-spiro[5.5]undec-9-yl]-ethanol (178944-69-9) + 8-(1-Benzenesulfonyl-1H-indol-2-yl)-9-(2-benzyloxy-ethyl)-1,5-dithia-9-aza-spiro[5.5]undecane (178944-68-8)

Guidance literature:

With 1.3-propanedithiol; boron trifluoride diethyl etherate; In dichloromethane; at 40 ℃; for 12h;

DOI:10.1016/0040-4020(96)00399-7

Reference yield: 40.0%

1.3-propanedithiol (109-80-8) + 7-(1-Benzenesulfonyl-1H-indol-2-yl)-8-(2-benzyloxy-ethyl)-1,4-dioxa-8-aza-spiro[4.5]decane (178944-67-7) → 2-[8-(1-Benzenesulfonyl-1H-indol-2-yl)-1,5-dithia-9-aza-spiro[5.5]undec-9-yl]-ethanol (178944-69-9) + 8-(1-Benzenesulfonyl-1H-indol-2-yl)-9-(2-benzyloxy-ethyl)-1,5-dithia-9-aza-spiro[5.5]undecane (178944-68-8)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at 40 ℃; for 12h;

DOI:10.1016/0040-4020(96)00399-7

upstream raw materials:

1.3-propanedithiol

7-(1-Benzenesulfonyl-1H-indol-2-yl)-8-(2-benzyloxy-ethyl)-1,4-dioxa-8-aza-spiro[4.5]decane

benzyl bromide

2-[8-(1-Benzenesulfonyl-1H-indol-2-yl)-1,5-dithia-9-aza-spiro[5.5]undec-9-yl]-ethanol

Downstream raw materials:

2-(1-Benzenesulfonyl-1H-indol-2-yl)-1-(2-benzyloxy-ethyl)-piperidin-4-one

C₃₅H₃₅N₃O₆S₂

C₃₅H₃₅N₃O₆S₂

2-(1-Benzenesulfonyl-1H-indol-2-yl)-1-(2-benzyloxy-ethyl)-piperidin-4-one oxime

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