(S)-1-benzyl 5-(2,5-dioxopyrrolidin-1-yl) 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate

Base Information

• Chemical Name: (S)-1-benzyl 5-(2,5-dioxopyrrolidin-1-yl) 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate
• CAS No.: 1209465-71-3
• Molecular Formula: C₃₁H₃₀N₆O₈
• Molecular Weight: 614.615
• Mol file: 1209465-71-3.mol

Synonyms:(S)-1-benzyl 5-(2,5-dioxopyrrolidin-1-yl) 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate

Chemical Property of (S)-1-benzyl 5-(2,5-dioxopyrrolidin-1-yl) 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-benzyl 5-(2,5-dioxopyrrolidin-1-yl) 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate

There total 2 articles about (S)-1-benzyl 5-(2,5-dioxopyrrolidin-1-yl) 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + (S)-4-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)-5-(benzyloxy)-5-oxopentanoic acid (204257-42-1) → (S)-1-benzyl 5-(2,5-dioxopyrrolidin-1-yl) 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate (1209465-71-3)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

Reference yield:

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid (137281-39-1) → (S)-1-benzyl 5-(2,5-dioxopyrrolidin-1-yl) 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate (1209465-71-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 4-methyl-morpholine / N,N-dimethyl-formamide / 1.5 h / 25 °C

2: N,N-dimethyl-formamide / 2 h / 25 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 48 h / 20 °C

With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

Reference yield:

(S)-1-benzyl 5-(2,5-dioxopyrrolidin-1-yl) 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate (1209465-71-3) → C24H24N6O8 (1209465-72-4)

Guidance literature:

With hydrogen; palladium;

upstream raw materials:

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

1-hydroxy-pyrrolidine-2,5-dione

(S)-4-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)-5-(benzyloxy)-5-oxopentanoic acid

Downstream raw materials:

C₂₄H₂₄N₆O₈