(2RS)-N-(1-(2',6'-dimethylphenoxy)-2-propyl)-tetrahydropyranyl-(R)-mandelamide

Base Information

Chemical Name:(2RS)-N-(1-(2',6'-dimethylphenoxy)-2-propyl)-tetrahydropyranyl-(R)-mandelamide
CAS No.:252049-70-0
Molecular Formula:C₂₄H₃₁NO₄
Molecular Weight:397.514
Hs Code.:

Synonyms:(2RS)-N-(1-(2',6'-dimethylphenoxy)-2-propyl)-tetrahydropyranyl-(R)-mandelamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2RS)-N-(1-(2',6'-dimethylphenoxy)-2-propyl)-tetrahydropyranyl-(R)-mandelamide

Chemical Property:

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Technology Process of (2RS)-N-(1-(2',6'-dimethylphenoxy)-2-propyl)-tetrahydropyranyl-(R)-mandelamide

There total 5 articles about (2RS)-N-(1-(2',6'-dimethylphenoxy)-2-propyl)-tetrahydropyranyl-(R)-mandelamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 31828-71-4
RS-mexiletine

: 156557-10-7
O^α-(tetrahydropyran-2-yl)-D-mandelic acid

: 252049-70-0
(2RS)-N-(1-(2',6'-dimethylphenoxy)-2-propyl)-tetrahydropyranyl-(R)-mandelamide

Guidance literature:: With dicyclohexyl-carbodiimide; In ethyl acetate; at 20 ℃; for 18h;
DOI:10.1016/S0957-4166(99)00311-0

Reference yield:

: 576-26-1,25134-01-4
2.6-dimethylphenol

: 252049-70-0
(2RS)-N-(1-(2',6'-dimethylphenoxy)-2-propyl)-tetrahydropyranyl-(R)-mandelamide

Guidance literature:: Multi-step reaction with 5 steps

1: aq. NaOH / ethanol / 6 h / 60 °C

2: pyridine / 4 h / 20 °C

3: 84 percent / NaN₃ / dimethylformamide / 2.5 h / 100 °C

4: 86 percent / H₂ / Raney nickel / methanol / 5 h / 20 °C / 760 Torr

5: 97 percent / dicyclohexylcarbodiimide / ethyl acetate / 18 h / 20 °C

With pyridine; sodium hydroxide; sodium azide; hydrogen; dicyclohexyl-carbodiimide; nickel; In methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide; 1: Etherification / 2: sulphonation / 3: azidation / 4: Catalytic hydrogenation / 5: amidation;
DOI:10.1016/S0957-4166(99)00311-0

Reference yield:

: 61102-09-8
(RS)-1-(2,6-dimethylphenoxy)propan-2-ol

: 252049-70-0
(2RS)-N-(1-(2',6'-dimethylphenoxy)-2-propyl)-tetrahydropyranyl-(R)-mandelamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 4 h / 20 °C

2: 84 percent / NaN₃ / dimethylformamide / 2.5 h / 100 °C

3: 86 percent / H₂ / Raney nickel / methanol / 5 h / 20 °C / 760 Torr

4: 97 percent / dicyclohexylcarbodiimide / ethyl acetate / 18 h / 20 °C

With pyridine; sodium azide; hydrogen; dicyclohexyl-carbodiimide; nickel; In methanol; ethyl acetate; N,N-dimethyl-formamide; 1: sulphonation / 2: azidation / 3: Catalytic hydrogenation / 4: amidation;
DOI:10.1016/S0957-4166(99)00311-0