4-(4-hydroxymethyl-2,5-dioxo-4-phenylimidazolidin-1-yl)-2-methoxybenzonitrile

Base Information

• Chemical Name: 4-(4-hydroxymethyl-2,5-dioxo-4-phenylimidazolidin-1-yl)-2-methoxybenzonitrile
• CAS No.: 1215102-60-5
• Molecular Formula: C₁₈H₁₅N₃O₄
• Molecular Weight: 337.335

Synonyms:4-(4-hydroxymethyl-2,5-dioxo-4-phenylimidazolidin-1-yl)-2-methoxybenzonitrile

Chemical Property of 4-(4-hydroxymethyl-2,5-dioxo-4-phenylimidazolidin-1-yl)-2-methoxybenzonitrile

Chemical Property:

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Technology Process of 4-(4-hydroxymethyl-2,5-dioxo-4-phenylimidazolidin-1-yl)-2-methoxybenzonitrile

There total 1 articles about 4-(4-hydroxymethyl-2,5-dioxo-4-phenylimidazolidin-1-yl)-2-methoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

4-cyano-3-methoxyphenyl isocyanate (84954-08-5) + 2-amino-3-hydroxy-2-phenylpropanoic acid (51196-55-5,6321-86-4) → 4-(4-hydroxymethyl-2,5-dioxo-4-phenylimidazolidin-1-yl)-2-methoxybenzonitrile (1215102-60-5)

Guidance literature:

4-cyano-3-methoxyphenyl isocyanate; 2-amino-3-hydroxy-2-phenylpropanoic acid; With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 18h;

With hydrogenchloride; In 1,4-dioxane; water; at 120 ℃; for 3h;

DOI:10.1021/jm300281x

Reference yield: 13.0%

4-(4-hydroxymethyl-2,5-dioxo-4-phenylimidazolidin-1-yl)-2-methoxybenzonitrile (1215102-60-5) + methyl iodide (74-88-4) → 4-(4-hydroxymethyl-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl)-2-methoxybenzonitrile (1215102-59-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/jm300281x

upstream raw materials:

4-cyano-3-methoxyphenyl isocyanate

2-amino-3-hydroxy-2-phenylpropanoic acid

Downstream raw materials:

4-(4-hydroxymethyl-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl)-2-methoxybenzonitrile

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