4-[(S)-2-azetidin-1-yl-1-(3-chloro-4-trifluoromethoxy-phenyl)-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylamide

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Chemical Name:4-[(S)-2-azetidin-1-yl-1-(3-chloro-4-trifluoromethoxy-phenyl)-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylamide
CAS No.:1612242-38-2
Molecular Formula:C₂₀H₁₈ClF₃N₆O₂
Molecular Weight:466.85
Hs Code.:

Synonyms:4-[(S)-2-azetidin-1-yl-1-(3-chloro-4-trifluoromethoxy-phenyl)-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylamide

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Chemical Property of 4-[(S)-2-azetidin-1-yl-1-(3-chloro-4-trifluoromethoxy-phenyl)-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylamide

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Technology Process of 4-[(S)-2-azetidin-1-yl-1-(3-chloro-4-trifluoromethoxy-phenyl)-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylamide

There total 14 articles about 4-[(S)-2-azetidin-1-yl-1-(3-chloro-4-trifluoromethoxy-phenyl)-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1612243-47-6
(S)-2-azetidin-1-yl-1-(3-chloro-4-trifluoromethoxy-phenyl)-ethylamine hydrochloride

: C₈H₅ClN₄O

: 1612242-38-2
4-[(S)-2-azetidin-1-yl-1-(3-chloro-4-trifluoromethoxy-phenyl)-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylamide

Guidance literature:: (S)-2-azetidin-1-yl-1-(3-chloro-4-trifluoromethoxy-phenyl)-ethylamine hydrochloride; With sodium sulfate; N-ethyl-N,N-diisopropylamine; In acetonitrile; for 0.0833333h;

C₈H₅ClN₄O; In acetonitrile; at 40 ℃;

Reference yield:

: 1612242-48-4
3-amino-pyridine-2,4-dicarboxylic acid diethyl ester

: 1612242-38-2
4-[(S)-2-azetidin-1-yl-1-(3-chloro-4-trifluoromethoxy-phenyl)-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 96 h / 140 °C

2.1: trichlorophosphate / 12 - 18 h / Reflux

3.1: sodium sulfate; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.08 h

3.2: 40 °C

With sodium sulfate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In acetonitrile;

Reference yield:

: 1074-76-6
2,4-dimethyl-3-nitropyridine

: 1612242-38-2
4-[(S)-2-azetidin-1-yl-1-(3-chloro-4-trifluoromethoxy-phenyl)-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / water / 90 °C

1.2: 16 h / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: hydrogen; palladium 10% on activated carbon / 4 h / 20 °C

4.1: 96 h / 140 °C

5.1: trichlorophosphate / 12 - 18 h / Reflux

6.1: sodium sulfate; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.08 h

6.2: 40 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; sodium sulfate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; In water; N,N-dimethyl-formamide; acetonitrile;