1074-76-6

Basic information

• Product Name: 2,4-Dimethyl-3-nitropyridine
• Synonyms: 2,4-DIMETHYL-3-NITROPYRIDINE;3-Nitro-2,4-dimethylpyridine;2,4-dimethyl-3-nitropyridine(SALTDATA: FREE);4-Methyl-pyriMido[1,2-b]pyridazin-2-one;2,4-DiMethyl-3-nitropyridine, 97%, 97%;Pyridine, 2,4-dimethyl-3-nitro-
• CAS NO: 1074-76-6
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.15
• Product Categories: Heterocycles;Heterocyclic Compound;Pyridines
• Mol File: 1074-76-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 9.5 °C
• Boiling Point: 233.601 °C at 760 mmHg
• Flash Point: 95.079 °C
• Appearance: /
• Density: 1.198 g/cm³
• Vapor Pressure: 0.084mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: 2-8°C
• PKA: 2.57±0.18(Predicted)
• CAS DataBase Reference: 2,4-Dimethyl-3-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dimethyl-3-nitropyridine(1074-76-6)
• EPA Substance Registry System: 2,4-Dimethyl-3-nitropyridine(1074-76-6)

Safety Data

• Hazardous Substances Data: 1074-76-6(Hazardous Substances Data)

Usage

Description

2,4-Dimethyl-3-nitropyridine is a chemical compound that belongs to the class of organic compounds known as pyridines and derivatives. It features a pyridine ring, a six-membered aromatic ring with one nitrogen atom, to which a nitro group (-NO2) is attached. This light yellow, strongly odorous substance is soluble in common organic solvents and requires careful handling due to its potential risks and hazards in usage and disposal.

Uses

Used in Organic Synthesis:
2,4-Dimethyl-3-nitropyridine is used as a key intermediate in the synthesis of various organic compounds. Its unique structure and reactivity make it a valuable building block for the development of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,4-Dimethyl-3-nitropyridine is used as a precursor for the synthesis of certain drugs. Its presence in the molecular structure can impart specific biological activities, making it an essential component in the development of new therapeutic agents.
Used in Agrochemical Industry:
2,4-Dimethyl-3-nitropyridine is also utilized in the agrochemical industry for the synthesis of pesticides and other crop protection agents. Its incorporation into these compounds can enhance their effectiveness in controlling pests and diseases, thereby contributing to increased crop yields and food security.
Used in Specialty Chemicals:
In the specialty chemicals sector, 2,4-Dimethyl-3-nitropyridine is employed as a raw material for the production of various high-value chemicals. Its versatility and unique properties make it suitable for applications in areas such as dyes, pigments, and other performance-enhancing additives.

InChI:InChI=1/C7H8N2O2/c1-5-3-4-8-6(2)7(5)9(10)11/h3-4H,1-2H3

Upstream product

• 583-61-9 2,3-Lutidine 
• 108-47-4 2,4-lutidine 
• 23056-45-3 2-bromo-3-nitro-4-methyl pyridine 
• 21203-62-3 4,6-dimethyl-5-nitro-pyridine-2-carboxylic acid 

Downstream Products

• 1427502-61-1 1-(7-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)ethanone 
• 1612241-91-4 4-[(S)-1-(3-fluoro-4-trifluoromethyl-phenyl)-2-methylamino-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylic acid amide 
• 1612242-58-6 C₂₄H₁₉F₄N₇O₅S 
• 1612242-38-2 4-[(S)-2-azetidin-1-yl-1-(3-chloro-4-trifluoromethoxy-phenyl)-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylamide 
• 1193-71-1 5-amino-2,4-dimethylpyridine 
• 108-47-4 2,4-lutidine 
• 480-98-8 7-methyl-1H-pyrrolo[2,3-c]pyridine 
• 143509-33-5 2,4-dimethyl-3-hydroxypyridine N-oxide 
• 143509-47-1 3-hydroxy-4-methylpyridine-2-carboxaldehyde 
• 27296-76-0 2,4-dimethyl-pyridin-3-ol 
• 21203-74-7 4-methyl-3-nitropyridine-2-carboxaldehyde 
• 1073-21-8 3-amino-2,4-dimethylpyridine 

Relevant articles and documents

Kras-G12C inhibitor heterocyclic compounds

The invention relates to Kras-G12C inhibitor heterocyclic compounds and a preparation method thereof, and application of the compounds in prevention and treatment of tumor diseases such as lung cancer, colorectal cancer and pancreatic cancer. In the preparation process, the compounds provided by the invention are obtained through a series of reactions such as a condensation reaction, an intramolecular cyclization reaction, a chlorination reaction, an SN2 reaction, a coupling reaction, deprotection and the like.

COMPOUNDS HAVING BOTH α7 NICOTINIC AGONIST ACTIVITY AND 5HT3 ANTAGONIST ACTIVITY FOR TREATMENT OF CNS DISEASES

The invention discloses compounds that are selective α7 nAChR agonists and 5-HT3 antagonists. The compounds are useful for treating many CNS diseases.

The synthesis of β-nitropyridine compounds

Pyridine and a number of substituted pyridines have been nitrated by reaction with N2O5 followed by reaction with an aqueous solution of SO2xH2O or NaHSO3. The dependence of the yields on the pH of the aqueous reaction medium, on the concentration of SO2xH2O-HSO3-, on addition of methanol to the aqueous phase, and on the reaction temperature were investigated. The yields obtained with NaHSO3 were: 3-nitropyridine 77%, 2-methyl-5-nitro-pyridine 36%, 3-methyl-5-nitropyridinc 24%, 3-acetyl-5-nitropyridine 18%, 5-nitropyridine-3-carboxylic acid 15%, 3-chloro-5-nitropyridine 11%, 4-methyl-3-nitropyridine 39%, 4-acetyl-3-nitropyridine 67%, 4-cyano-3-nitropyridine 45%, 4-phenyl-3-nitropyridine 68%, 4-formyl-3-nitropyridine 62% (from reaction in liquid SO2), 3-nitropyridine-4-carboxylic acid 48%, methyl 3-nitropyridine-4-carboxylate 75%, 2,3-dimethyl-5-nitropyridine 37%, 2,4-dimethyl-5-nitropyridine 64%, 3-nitroquinoline 10% and 4-nitroisoquinoline 42%.