9-O-(2-flouro-4-triflouromethylbenzoyl)berberrubine chloride

Base Information

• Chemical Name: 9-O-(2-flouro-4-triflouromethylbenzoyl)berberrubine chloride
• CAS No.: 1297302-84-1
• Molecular Formula: C₂₇H₁₈F₄NO₅*Cl
• Molecular Weight: 547.89
• Mol file: 1297302-84-1.mol

Synonyms:9-O-(2-flouro-4-triflouromethylbenzoyl)berberrubine chloride

Chemical Property of 9-O-(2-flouro-4-triflouromethylbenzoyl)berberrubine chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-O-(2-flouro-4-triflouromethylbenzoyl)berberrubine chloride

There total 3 articles about 9-O-(2-flouro-4-triflouromethylbenzoyl)berberrubine chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

berberrubine chloride (15401-69-1) + 2-fluoro-4-(trifluoromethyl)benzoyl chloride (126917-10-0) → 9-O-(2-flouro-4-triflouromethylbenzoyl)berberrubine chloride (1297302-84-1)

Guidance literature:

In acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1016/j.ejmech.2011.01.016

Reference yield: 90.6%

→ 9-O-(2-flouro-4-triflouromethylbenzoyl)berberrubine chloride (1297302-84-1)

Guidance literature:

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 0.25h;

With dmap; In N,N-dimethyl-formamide; at 60 ℃; for 1.5h;

Reference yield:

berberine chloride (633-65-8) → 9-O-(2-flouro-4-triflouromethylbenzoyl)berberrubine chloride (1297302-84-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 190 °C / 20 - 30 Torr

2: acetonitrile / 0.5 h / 20 °C

In acetonitrile;

DOI:10.1016/j.ejmech.2011.01.016

upstream raw materials:

berberrubine chloride

2-fluoro-4-(trifluoromethyl)benzoyl chloride

berberine chloride