(2S)-2-{[(1Z)-1-benzyl-3-oxo-3-piperidin-1-ylprop-1-en-1-yl]amino}-2-phenylacetamide

Base Information

Chemical Name:(2S)-2-{[(1Z)-1-benzyl-3-oxo-3-piperidin-1-ylprop-1-en-1-yl]amino}-2-phenylacetamide
CAS No.:679789-08-3
Molecular Formula:C₂₃H₂₇N₃O₂
Molecular Weight:377.486
Hs Code.:

Synonyms:(2S)-2-{[(1Z)-1-benzyl-3-oxo-3-piperidin-1-ylprop-1-en-1-yl]amino}-2-phenylacetamide

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Chemical Property of (2S)-2-{[(1Z)-1-benzyl-3-oxo-3-piperidin-1-ylprop-1-en-1-yl]amino}-2-phenylacetamide

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Technology Process of (2S)-2-{[(1Z)-1-benzyl-3-oxo-3-piperidin-1-ylprop-1-en-1-yl]amino}-2-phenylacetamide

There total 1 articles about (2S)-2-{[(1Z)-1-benzyl-3-oxo-3-piperidin-1-ylprop-1-en-1-yl]amino}-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 6485-52-5
L-phenylglycine amide

: 146380-08-7
4-oxo-1-phenyl-4-piperidin-1-ylbutan-2-one

: 679789-08-3
(2S)-2-{[(1Z)-1-benzyl-3-oxo-3-piperidin-1-ylprop-1-en-1-yl]amino}-2-phenylacetamide

Guidance literature:: With acetic acid; In methanol; at 40 ℃; for 72h;
DOI:10.1021/ja038812t

Reference yield: 88.0%

: 679789-08-3
(2S)-2-{[(1Z)-1-benzyl-3-oxo-3-piperidin-1-ylprop-1-en-1-yl]amino}-2-phenylacetamide

: 679789-19-6
(2S)-2-{[(1R)-1-benzyl-3-oxo-3-piperidin-1-ylpropyl]amino}-2-phenylacetamide

Guidance literature:: With hydrogen; platinum(IV) oxide; In tetrahydrofuran; for 24h; under 4654.33 Torr;
DOI:10.1021/ja038812t

Reference yield:

: 679789-08-3
(2S)-2-{[(1Z)-1-benzyl-3-oxo-3-piperidin-1-ylprop-1-en-1-yl]amino}-2-phenylacetamide

: [(1R)-1-benzyl-3-oxo-3-piperidin-1-ylpropyl]amine acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / H₂ / PtO₂ / tetrahydrofuran / 24 h / 4654.33 Torr

2: 92 percent Spectr_. / H₂ / Pd(OH)2 / H₂O; tetrahydrofuran / 12 h / 2068.59 Torr

With hydrogen; platinum(IV) oxide; palladium dihydroxide; In tetrahydrofuran; water;
DOI:10.1021/ja038812t