Technology Process of (N,N-dipentyl,Leu5)enkephalin
There total 13 articles about (N,N-dipentyl,Leu5)enkephalin which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
methoxybenzene; trifluoroacetic acid;
In
dichloromethane;
at 25 ℃;
for 3h;
DOI:10.1021/jm00390a005
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, 2.) THF, DMF
2: ammonium formate / 10percent Pd/C / methanol
3: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, 2.) THF, DMF
4: 91.9 percent / ammonium formate, H2 / 10percent Pd/C / methanol / 0.67 h
5: 36.8 percent / N,N-diisopropylethylamine / toluene / 4 h / Heating
6: 46.7 percent / 0.25 N NaOH / tetrahydrofuran / 6 h / 25 °C
7: 56 percent / 50percent CF3COOH, 10percent anisole / CH2Cl2 / 3 h / 25 °C
With
4-methyl-morpholine; sodium hydroxide; hydrogen; ammonium formate; methoxybenzene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; isobutyl chloroformate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jm00390a005
- Guidance literature:
-
Multi-step reaction with 6 steps
1: ammonium formate / 10percent Pd/C / methanol
2: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, 2.) THF, DMF
3: 91.9 percent / ammonium formate, H2 / 10percent Pd/C / methanol / 0.67 h
4: 36.8 percent / N,N-diisopropylethylamine / toluene / 4 h / Heating
5: 46.7 percent / 0.25 N NaOH / tetrahydrofuran / 6 h / 25 °C
6: 56 percent / 50percent CF3COOH, 10percent anisole / CH2Cl2 / 3 h / 25 °C
With
4-methyl-morpholine; sodium hydroxide; hydrogen; ammonium formate; methoxybenzene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; isobutyl chloroformate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jm00390a005
![(S)-2-[(S)-2-(2-{2-[(S)-3-(4-tert-Butoxy-phenyl)-2-dipentylamino-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid](/Databaselist/images/loading.webp)
