1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carbonitrile

Base Information

Chemical Name:1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carbonitrile
CAS No.:1334527-88-6
Molecular Formula:C₁₄H₁₂FN₃
Molecular Weight:241.268
Hs Code.:

Synonyms:1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carbonitrile

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Chemical Property of 1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carbonitrile

Chemical Property:

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Technology Process of 1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carbonitrile

There total 4 articles about 1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 446-48-0
o-fluorobenzyl bromide

: 851776-29-9
1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carbonitrile

: 1334527-88-6
1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carbonitrile

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1334527-87-5
C₁₄H₁₄FN₃O

: 1334527-88-6
1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carbonitrile

Guidance literature:: With pyridine; trifluoroacetic anhydride; at 0 ℃;

Reference yield:

: 1334528-03-8
C₁₆H₁₇FN₂O₂

: 1334527-88-6
1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia / sodium cyanide / methanol / 90 °C

2: trifluoroacetic anhydride; pyridine / 0 °C

With pyridine; ammonia; trifluoroacetic anhydride; sodium cyanide; In methanol;