1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboximidamide

Base Information

Chemical Name:1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboximidamide
CAS No.:1334527-89-7
Molecular Formula:C₁₄H₁₅FN₄
Molecular Weight:258.298
Hs Code.:

Synonyms:1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboximidamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboximidamide

Chemical Property:

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Technology Process of 1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboximidamide

There total 6 articles about 1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1334527-88-6
1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carbonitrile

: 1334527-89-7
1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboximidamide

Guidance literature:: 1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carbonitrile; With sodium methylate; In methanol; at 20 ℃; for 4h; Inert atmosphere;

With ammonium chloride; acetic acid; In methanol; at 50 ℃;

Reference yield:

: 1334528-03-8
C₁₆H₁₇FN₂O₂

: 1334527-89-7
1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboximidamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / sodium cyanide / methanol / 90 °C

2.1: trifluoroacetic anhydride; pyridine / 0 °C

3.1: sodium methylate / methanol / 3 h / 40 °C

3.2: Reflux

With pyridine; ammonia; sodium methylate; trifluoroacetic anhydride; sodium cyanide; In methanol;

Reference yield:

: 446-48-0
o-fluorobenzyl bromide

: 1334527-89-7
1-(2-fluorobenzyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboximidamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: sodium methylate / methanol / 4 h / 20 °C / Inert atmosphere

2.2: 50 °C / Inert atmosphere

With sodium methylate; caesium carbonate; In methanol; N,N-dimethyl-formamide;