6-((3S,4R)-7-Methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-4-propyl-3,4-dihydro-2H-benzo[1,4]oxazine; hydrochloride

Base Information

Chemical Name:6-((3S,4R)-7-Methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-4-propyl-3,4-dihydro-2H-benzo[1,4]oxazine; hydrochloride
CAS No.:78838-45-6
Molecular Formula:C₂₉H₃₃NO₃*ClH
Molecular Weight:480.047
Hs Code.:

Synonyms:6-((3S,4R)-7-Methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-4-propyl-3,4-dihydro-2H-benzo[1,4]oxazine; hydrochloride

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Chemical Property of 6-((3S,4R)-7-Methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-4-propyl-3,4-dihydro-2H-benzo[1,4]oxazine; hydrochloride

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Technology Process of 6-((3S,4R)-7-Methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-4-propyl-3,4-dihydro-2H-benzo[1,4]oxazine; hydrochloride

There total 7 articles about 6-((3S,4R)-7-Methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-4-propyl-3,4-dihydro-2H-benzo[1,4]oxazine; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 78838-41-2
6-<4'-(3',4'-cis-7'-Methoxy-2',2'-dimethyl-3'-phenyl)chromanyl>dihydrobenz-1,4-oxazine

: 78838-45-6
6-((3S,4R)-7-Methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-4-propyl-3,4-dihydro-2H-benzo[1,4]oxazine; hydrochloride

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 24h; Ambient temperature;

Reference yield:

: 51423-18-8
cis-2,2-Dimethyl-3-phenyl-4-(p-hydroxyphenyl)-7-methoxychroman

: 78838-45-6
6-((3S,4R)-7-Methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-4-propyl-3,4-dihydro-2H-benzo[1,4]oxazine; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / conc. HNO₃ / acetic acid / 0.5 h / 8 - 10 °C

2: 65 percent / H₂ / 10percent Pd/C / methanol / 1 h / 2585.7 Torr

3: K₂CO₃ / acetone

4: 80 percent / K₂CO₃ / dimethylformamide / 24 h / Ambient temperature

With hydrogen; nitric acid; potassium carbonate; palladium on activated charcoal; In methanol; acetic acid; N,N-dimethyl-formamide; acetone;

Reference yield:

: 78838-23-0,78838-24-1
3,4-cis-7-Methoxy-2,2-dimethyl-3-phenyl-4-(4'-hydroxy-3'-nitrophenyl)chroman

: 78838-45-6
6-((3S,4R)-7-Methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-4-propyl-3,4-dihydro-2H-benzo[1,4]oxazine; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / H₂ / 10percent Pd/C / methanol / 1 h / 2585.7 Torr

2: K₂CO₃ / acetone

3: 80 percent / K₂CO₃ / dimethylformamide / 24 h / Ambient temperature

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetone;