2-((2S,4S)-1-(4-(3-Chloro-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Base Information

• Chemical Name: 2-((2S,4S)-1-(4-(3-Chloro-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt
• CAS No.: 1283142-69-7
• Molecular Formula: C₂HF₃O₂*C₂₀H₁₉ClF₃NO₃
• Molecular Weight: 527.848
• Mol file: 1283142-69-7.mol

Synonyms:2-((2S,4S)-1-(4-(3-Chloro-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Chemical Property of 2-((2S,4S)-1-(4-(3-Chloro-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((2S,4S)-1-(4-(3-Chloro-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

There total 10 articles about 2-((2S,4S)-1-(4-(3-Chloro-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-((2S,4S)-1-(4-(3-chloro-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile (1283146-26-8) + trifluoroacetic acid (76-05-1) → 2-((2S,4S)-1-(4-(3-Chloro-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt (1283142-69-7)

Guidance literature:

2-((2S,4S)-1-(4-(3-chloro-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile; With potassium hydroxide; In ethanol; water; at 120 ℃; for 2h; Sealed tube;

trifluoroacetic acid; In water; acetonitrile;

DOI:10.1021/acs.jmedchem.6b01559

Reference yield:

(2S,4S)-tert-butyl 2-(hydroxymethyl)-4-(trifluoromethyl)pyrrolidine-1-carboxylate (470482-40-7) → 2-((2S,4S)-1-(4-(3-Chloro-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt (1283142-69-7)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

2: copper(l) iodide; sodium hydroxide / isopropyl alcohol / 90 °C / Inert atmosphere; Sealed tube

3: triethylamine / dichloromethane / 1 h / 0 °C

4: dimethyl sulfoxide / 50 °C

5: potassium hydroxide / water; ethanol / 2 h / 120 °C / Sealed tube

With hydrogenchloride; copper(l) iodide; triethylamine; potassium hydroxide; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol;

DOI:10.1021/acs.jmedchem.6b01559

Reference yield:

((2S,4S)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol hydrochloride (1283146-07-5) → 2-((2S,4S)-1-(4-(3-Chloro-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt (1283142-69-7)

Guidance literature:

Multi-step reaction with 4 steps

1: copper(l) iodide; sodium hydroxide / isopropyl alcohol / 90 °C / Inert atmosphere; Sealed tube

2: triethylamine / dichloromethane / 1 h / 0 °C

3: dimethyl sulfoxide / 50 °C

4: potassium hydroxide / water; ethanol / 2 h / 120 °C / Sealed tube

With copper(l) iodide; triethylamine; potassium hydroxide; sodium hydroxide; In ethanol; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol;

DOI:10.1021/acs.jmedchem.6b01559

upstream raw materials:

(2S,4S)-tert-butyl 2-(hydroxymethyl)-4-(trifluoromethyl)pyrrolidine-1-carboxylate

((2S,4S)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol hydrochloride

4-iodophenylboronic acid

3-chloro-o-cresol