2-((2S,4S)-1-(4-(3-chloro-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

Base Information

Chemical Name:2-((2S,4S)-1-(4-(3-chloro-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile
CAS No.:1283146-26-8
Molecular Formula:C₂₀H₁₈ClF₃N₂O
Molecular Weight:394.824
Hs Code.:

Synonyms:2-((2S,4S)-1-(4-(3-chloro-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

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Chemical Property of 2-((2S,4S)-1-(4-(3-chloro-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

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Technology Process of 2-((2S,4S)-1-(4-(3-chloro-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

There total 8 articles about 2-((2S,4S)-1-(4-(3-chloro-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1283146-07-5
((2S,4S)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol hydrochloride

: 1283146-26-8
2-((2S,4S)-1-(4-(3-chloro-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; sodium hydroxide / isopropyl alcohol / 90 °C / Inert atmosphere; Sealed tube

2: triethylamine / dichloromethane / 1 h / 0 °C

3: dimethyl sulfoxide / 50 °C

With copper(l) iodide; triethylamine; sodium hydroxide; In dichloromethane; dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1021/acs.jmedchem.6b01559

Reference yield:

: 1283146-25-7
((2S,4S)-1-(4-(3-chloro-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol

: 1283146-26-8
2-((2S,4S)-1-(4-(3-chloro-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 0 °C

2: dimethyl sulfoxide / 50 °C

With triethylamine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/acs.jmedchem.6b01559

Reference yield:

: 3260-87-5
3-chloro-o-cresol

: 1283146-26-8
2-((2S,4S)-1-(4-(3-chloro-2-methylphenoxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; copper diacetate / dichloromethane / Molecular sieve

2: copper(l) iodide; sodium hydroxide / isopropyl alcohol / 90 °C / Inert atmosphere; Sealed tube

3: triethylamine / dichloromethane / 1 h / 0 °C

4: dimethyl sulfoxide / 50 °C

With copper(l) iodide; copper diacetate; triethylamine; sodium hydroxide; In dichloromethane; dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1021/acs.jmedchem.6b01559