tert-butyl 2-(6-(4-methylpiperazin-1-yl)nicotinamido)-4-(thiophen-2-yl)phenylcarbamate

Base Information

Chemical Name:tert-butyl 2-(6-(4-methylpiperazin-1-yl)nicotinamido)-4-(thiophen-2-yl)phenylcarbamate
CAS No.:953434-82-7
Molecular Formula:C₂₆H₃₁N₅O₃S
Molecular Weight:493.63
Hs Code.:

Synonyms:tert-butyl 2-(6-(4-methylpiperazin-1-yl)nicotinamido)-4-(thiophen-2-yl)phenylcarbamate

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Chemical Property of tert-butyl 2-(6-(4-methylpiperazin-1-yl)nicotinamido)-4-(thiophen-2-yl)phenylcarbamate

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Technology Process of tert-butyl 2-(6-(4-methylpiperazin-1-yl)nicotinamido)-4-(thiophen-2-yl)phenylcarbamate

There total 5 articles about tert-butyl 2-(6-(4-methylpiperazin-1-yl)nicotinamido)-4-(thiophen-2-yl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 109-01-3
1-methyl-piperazine

: 937728-82-0
tert-butyl N-(2-(6-chloronicotinamido)-4-(thiophen-2-yl)phenyl)carbamate

: 953434-82-7
tert-butyl 2-(6-(4-methylpiperazin-1-yl)nicotinamido)-4-(thiophen-2-yl)phenylcarbamate

Guidance literature:: at 90 ℃; for 18h;

Reference yield:

: 132521-70-1
6-(4-methylpiperazin-1-yl)nicotinic acid

: 335255-43-1
tert-butyl 2-amino-4-(thiophen-2-yl)phenylcarbamate

: 953434-82-7
tert-butyl 2-(6-(4-methylpiperazin-1-yl)nicotinamido)-4-(thiophen-2-yl)phenylcarbamate

Guidance literature:: With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 20 ℃;

Reference yield:

: 73781-91-6
6-Chloronicotinic acid methyl ester

: 953434-82-7
tert-butyl 2-(6-(4-methylpiperazin-1-yl)nicotinamido)-4-(thiophen-2-yl)phenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 100 °C / Inert atmosphere

2: sodium hydroxide; ethanol / tetrahydrofuran / 3 h / 60 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / 20 °C

With pyridine; ethanol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane;