N-Benzoyl-β-alanine chloride

Base Information

• Chemical Name: N-Benzoyl-β-alanine chloride
• CAS No.: 43218-34-4
• Molecular Formula: C₁₀H₁₀ClNO₂
• Molecular Weight: 211.648
• Mol file: 43218-34-4.mol

Synonyms:N-Benzoyl-β-alanine chloride

Chemical Property of N-Benzoyl-β-alanine chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Benzoyl-β-alanine chloride

There total 1 articles about N-Benzoyl-β-alanine chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzoyl-beta-alanine (3440-28-6) → N-Benzoyl-β-alanine chloride (43218-34-4)

Guidance literature:

With phosphorus pentachloride; acetyl chloride;

Reference yield: 85.0%

N-Benzoyl-β-alanine chloride (43218-34-4) + (4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one (92841-65-1) → (4R,5S)-1,5-Dimethyl-3-[(3'-N-benzoylamino)propanoyl]-4-phenylimidazolidin-2-one (252580-15-7)

Guidance literature:

(4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one; With methylmagnesium chloride; In tetrahydrofuran; at 0 ℃; for 0.5h;

N-Benzoyl-β-alanine chloride; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1055/s-1999-2927

Reference yield:

N-Benzoyl-β-alanine chloride (43218-34-4) → (4R,5S,5'S)-1,5-Dimethyl-3-(2'-phenyl-4'-oxazolylcarbonyl)-4-phenylimidazolidin-2-one (252580-16-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: MeMgCl / tetrahydrofuran / 0.5 h / 0 °C

1.2: 85 percent / tetrahydrofuran / 4 h / 20 °C

2.1: LiHMDS / tetrahydrofuran / 0.5 h / 0 °C

2.2: I₂ / tetrahydrofuran / 1 h / -100 °C

With methylmagnesium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; 1.1: Metallation / 1.2: Substitution / 2.1: Metallation / 2.2: Cyclization;

DOI:10.1055/s-1999-2927

upstream raw materials:

N-benzoyl-beta-alanine

Downstream raw materials:

N-(3-oxo-3-phenylpropyl)benzamide

(4R,5S)-1,5-Dimethyl-3-[(3'-N-benzoylamino)propanoyl]-4-phenylimidazolidin-2-one

(4R,5S,5'S)-1,5-Dimethyl-3-(2'-phenyl-4'-oxazolylcarbonyl)-4-phenylimidazolidin-2-one