(+)-(S)-N-methyl-N-<(1S,2S)-1-methyl-2-phenylethan-2-ol>-methylphenylphosphinamidothioate

Base Information

• Chemical Name: (+)-(S)-N-methyl-N-<(1S,2S)-1-methyl-2-phenylethan-2-ol>-methylphenylphosphinamidothioate
• CAS No.: 76231-81-7
• Molecular Formula: C₁₇H₂₂NOPS
• Molecular Weight: 319.408
• Mol file: 76231-81-7.mol

Synonyms:(+)-(S)-N-methyl-N-<(1S,2S)-1-methyl-2-phenylethan-2-ol>-methylphenylphosphinamidothioate

Chemical Property of (+)-(S)-N-methyl-N-<(1S,2S)-1-methyl-2-phenylethan-2-ol>-methylphenylphosphinamidothioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-(S)-N-methyl-N-<(1S,2S)-1-methyl-2-phenylethan-2-ol>-methylphenylphosphinamidothioate

There total 1 articles about (+)-(S)-N-methyl-N-<(1S,2S)-1-methyl-2-phenylethan-2-ol>-methylphenylphosphinamidothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

(2R,4S,5S)-2,3,4-trimethyl-5-phenyl-1,3,2-oxazaphospholidine-2-thione (66213-06-7) + phenylmagnesium bromide → (-)-(S)-methylphenylphosphinothioic acid (35556-64-0) + (+)-(S)-N-methyl-N-<(1S,2S)-1-methyl-2-phenylethan-2-ol>-methylphenylphosphinamidothioate (76231-81-7)

Guidance literature:

In benzene; for 5h;

Reference yield: 90.0%

acetic anhydride (108-24-7) + (+)-(S)-N-methyl-N-<(1S,2S)-1-methyl-2-phenylethan-2-ol>-methylphenylphosphinamidothioate (76231-81-7) → (+)-(S)-N-methyl-N-<(1S,2S)-1-methyl-2-acetyl-2-phenylethyl>-methylphenylphosphinoamidothioate (73144-37-3,73176-33-7)

Guidance literature:

With pyridine;

Reference yield: 86.0%

(+)-(S)-N-methyl-N-<(1S,2S)-1-methyl-2-phenylethan-2-ol>-methylphenylphosphinamidothioate (76231-81-7) → (+)-(R)-methylphenylphosphinothioic acid (38607-73-7)

Guidance literature:

With hydrogenchloride; In acetone; for 5h;

upstream raw materials:

(2R,4S,5S)-2,3,4-trimethyl-5-phenyl-1,3,2-oxazaphospholidine-2-thione

Downstream raw materials:

(+)-(S)-N-methyl-N-<(1S,2S)-1-methyl-2-acetyl-2-phenylethyl>-methylphenylphosphinoamidothioate

(+)-(R)-methylphenylphosphinothioic acid