2-(β-D-ribofuranosyl)-4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-phenylpyrimidine

Base Information

Chemical Name:2-(β-D-ribofuranosyl)-4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-phenylpyrimidine
CAS No.:1442648-69-2
Molecular Formula:C₂₅H₂₃ClN₄O₄
Molecular Weight:478.935
Hs Code.:

Synonyms:2-(β-D-ribofuranosyl)-4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-phenylpyrimidine

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Chemical Property of 2-(β-D-ribofuranosyl)-4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-phenylpyrimidine

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Technology Process of 2-(β-D-ribofuranosyl)-4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-phenylpyrimidine

There total 4 articles about 2-(β-D-ribofuranosyl)-4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-phenylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1370690-10-0
1-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-3-phenylprop-2-yn-1-one

: 110537-81-0
1-(β-D-ribofuranosyl)formamidine hydrochloride

: 1442648-69-2
2-(β-D-ribofuranosyl)-4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-phenylpyrimidine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 4h; Molecular sieve; Inert atmosphere;
DOI:10.1002/ejoc.201300107

Reference yield:

: 13035-61-5
1,2,3,5-tetraacetylribose

: 1442648-69-2
2-(β-D-ribofuranosyl)-4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-phenylpyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: tin(IV) chloride / dichloromethane / 30 h / 20 °C / Reflux

2: sodium methylate / 72 h

3: ammonium chloride; ammonia / methanol / 72 h

4: potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C / Molecular sieve; Inert atmosphere

With ammonia; sodium methylate; tin(IV) chloride; potassium carbonate; ammonium chloride; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201300107

Reference yield:

: 62404-62-0
β-D-ribofuranosyl-1-carboximidic acid methyl ester

: 1442648-69-2
2-(β-D-ribofuranosyl)-4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-phenylpyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium chloride; ammonia / methanol / 72 h

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C / Molecular sieve; Inert atmosphere

With ammonia; potassium carbonate; ammonium chloride; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201300107