1-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-3-phenylprop-2-yn-1-one

Base Information

Chemical Name:1-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-3-phenylprop-2-yn-1-one
CAS No.:1370690-10-0
Molecular Formula:C₁₉H₁₃ClN₂O
Molecular Weight:320.778
Hs Code.:

Synonyms:1-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-3-phenylprop-2-yn-1-one

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Chemical Property of 1-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-3-phenylprop-2-yn-1-one

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Technology Process of 1-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-3-phenylprop-2-yn-1-one

There total 4 articles about 1-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-3-phenylprop-2-yn-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 188047-58-7
5-chloro-3-methyl-1-phenyl-1H-pyrazole-4?carbonyl chloride

: 536-74-3
phenylacetylene

: 1370690-10-0
1-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-3-phenylprop-2-yn-1-one

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In 1,4-dioxane; at 70 ℃; for 3h; regioselective reaction; Inert atmosphere;
DOI:10.1039/c2ob07030h

Reference yield:

: C₁₉H₁₅ClN₂O

: 1370690-10-0
1-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-3-phenylprop-2-yn-1-one

Guidance literature:: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; at 20 ℃; for 2h;
DOI:10.1021/acs.joc.0c02087

Reference yield:

: 947-95-5
5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole

: 1370690-10-0
1-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-3-phenylprop-2-yn-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium permanganate / acetone / 12 h / 20 °C / Inert atmosphere

2: thionyl chloride / 3 h / Inert atmosphere; Reflux

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 3 h / 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; potassium permanganate; copper(l) iodide; thionyl chloride; In 1,4-dioxane; acetone; 3: Sonogashira coupling;
DOI:10.1039/c2ob07030h