N-(4-Nitrophenyl)-N'-[4-[(4,5-dimethoxy-2-ethoxycarbonylphenyl)-aminocarbonyl]phenyl]urea

Base Information

• Chemical Name: N-(4-Nitrophenyl)-N'-[4-[(4,5-dimethoxy-2-ethoxycarbonylphenyl)-aminocarbonyl]phenyl]urea
• CAS No.: 334024-93-0
• Molecular Formula: C₂₅H₂₄N₄O₈
• Molecular Weight: 508.488
• Mol file: 334024-93-0.mol

Synonyms:N-(4-Nitrophenyl)-N'-[4-[(4,5-dimethoxy-2-ethoxycarbonylphenyl)-aminocarbonyl]phenyl]urea

Chemical Property of N-(4-Nitrophenyl)-N'-[4-[(4,5-dimethoxy-2-ethoxycarbonylphenyl)-aminocarbonyl]phenyl]urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-Nitrophenyl)-N'-[4-[(4,5-dimethoxy-2-ethoxycarbonylphenyl)-aminocarbonyl]phenyl]urea

There total 6 articles about N-(4-Nitrophenyl)-N'-[4-[(4,5-dimethoxy-2-ethoxycarbonylphenyl)-aminocarbonyl]phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-Nitrophenyl isocyanate (100-28-7) + ethyl 2-(4-aminophenyl)carbonylamino-4,5-dimethoxybenzoate (334025-77-3) → N-(4-Nitrophenyl)-N'-[4-[(4,5-dimethoxy-2-ethoxycarbonylphenyl)-aminocarbonyl]phenyl]urea (334024-93-0)

Guidance literature:

With dmap; In tetrahydrofuran; Heating;

DOI:10.1016/S0968-0896(02)00012-3

Reference yield:

4,5-dimethoxy-2-nitro-benzoic acid (4998-07-6) → N-(4-Nitrophenyl)-N'-[4-[(4,5-dimethoxy-2-ethoxycarbonylphenyl)-aminocarbonyl]phenyl]urea (334024-93-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 63 percent / H₂SO₄ / 18 h / Heating

2: 98 percent / H₂ / Pd/C / ethanol / 14 h / 20 °C

3: Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

4: 0.28 g / H₂ / Pd/C / methanol / 32 h

5: 63 percent / DMAP / tetrahydrofuran / Heating

With dmap; sulfuric acid; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;

DOI:10.1016/S0968-0896(02)00012-3

Reference yield:

2-carboethoxy-4,5-dimethoxyaniline (20323-74-4) → N-(4-Nitrophenyl)-N'-[4-[(4,5-dimethoxy-2-ethoxycarbonylphenyl)-aminocarbonyl]phenyl]urea (334024-93-0)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

2: 0.28 g / H₂ / Pd/C / methanol / 32 h

3: 63 percent / DMAP / tetrahydrofuran / Heating

With dmap; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/S0968-0896(02)00012-3

upstream raw materials:

4-Nitrophenyl isocyanate

ethyl 2-(4-aminophenyl)carbonylamino-4,5-dimethoxybenzoate

4,5-dimethoxy-2-nitro-benzoic acid

2-carboethoxy-4,5-dimethoxyaniline