334025-77-3

Upstream product

• 4998-07-6 4,5-dimethoxy-2-nitro-benzoic acid 
• 334025-76-2 4,5-dimethoxy-2-(4-nitro-benzoylamino)-benzoic acid ethyl ester 
• 100905-33-7 ethyl 2-nitro-4,5-dimethoxybenzoate 
• 20323-74-4 2-carboethoxy-4,5-dimethoxyaniline 

Downstream Products

• 334024-93-0 N-(4-Nitrophenyl)-N'-[4-[(4,5-dimethoxy-2-ethoxycarbonylphenyl)-aminocarbonyl]phenyl]urea 
• 334025-50-2 Benzyl-{4-[(4,5-dimethoxy-2-ethoxycarbonylphenyl)aminocarbonyl]-phenyl}carbamate 

Relevant academic research and scientific papers

Synthesis and structure-activity relationship of diarylamide urea derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells.

A series of diarylamide urea derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells (ECs). Compound 2o was superior to the lead compound, Tranilast, in terms of its potency of the inhibitory activity and cell selectivity.

NOVEL DIARYLAMIDE DERIVATIVES AND USE THEREOF AS MEDICINES

This invention relates to a diarylamide derivative represented by formula (1) or a salt thereof and a pharmaceutical composition comprising, as an active ingredient, the compound: wherein, ???A and B denote an aromatic ring such as a benzene ring; COY and NHCOX are adjacent to each other and these substituents are linked to carbon in the aromatic ring A; X denotes alkylene, alkyleneoxy, or a single bond; Y denotes an alkyl, alkoxy, hydroxyl, or substituted or unsubstituted amino group; R1 denotes hydrogen, halogen, hydroxyl, alkyl or the like, provided that, when A denotes a benzene ring, R1 does not denote hydrogen; R2 denotes hydrogen, halogen, hydroxyl, alkyl or the like; R3 and R4 denote a substituted or unsubstituted imino group, an oxygen atom, or a single bond; R5 denotes alkyl, substituted or unsubstituted phenyl or the like; and Z denotes oxygen or sulfur.