2'-((1H-tetrazol-5-yl)methyl)-5'-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropane-carboxamido)-N,N-dimethylbiphenyl-4-carboxamide

Base Information

Chemical Name:2'-((1H-tetrazol-5-yl)methyl)-5'-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropane-carboxamido)-N,N-dimethylbiphenyl-4-carboxamide
CAS No.:945232-90-6
Molecular Formula:C₂₈H₂₆N₆O₄
Molecular Weight:510.552
Hs Code.:

Synonyms:2'-((1H-tetrazol-5-yl)methyl)-5'-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropane-carboxamido)-N,N-dimethylbiphenyl-4-carboxamide

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Chemical Property of 2'-((1H-tetrazol-5-yl)methyl)-5'-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropane-carboxamido)-N,N-dimethylbiphenyl-4-carboxamide

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Technology Process of 2'-((1H-tetrazol-5-yl)methyl)-5'-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropane-carboxamido)-N,N-dimethylbiphenyl-4-carboxamide

There total 4 articles about 2'-((1H-tetrazol-5-yl)methyl)-5'-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropane-carboxamido)-N,N-dimethylbiphenyl-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 945240-99-3
5'-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-2'-(cyanomethyl)-N,N-dimethylbiphenyl-4-carboxamide

: 945232-90-6
2'-((1H-tetrazol-5-yl)methyl)-5'-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropane-carboxamido)-N,N-dimethylbiphenyl-4-carboxamide

Guidance literature:: With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 100 ℃; for 2h; Microwave irradiation;

Reference yield:

: 945244-47-3
methyl 4-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-2-bromobenzoate

: 945232-90-6
2'-((1H-tetrazol-5-yl)methyl)-5'-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropane-carboxamido)-N,N-dimethylbiphenyl-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: lithium borohydride / diethyl ether; tetrahydrofuran; water / 16 h / 25 °C

2: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / acetonitrile / 336 h

3: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 150 °C / Microwave irradiation

4: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 2 h / 100 °C / Microwave irradiation

With lithium borohydride; sodium azide; potassium carbonate; ammonium chloride; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 945244-17-7
1-(benzo[d][1,3]dioxol-5-yl)-N-(3-bromo-4-(hydroxymethyl)phenyl)cyclopropanecarboxamide

: 945232-90-6
2'-((1H-tetrazol-5-yl)methyl)-5'-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropane-carboxamido)-N,N-dimethylbiphenyl-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / acetonitrile / 336 h

2: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 150 °C / Microwave irradiation

3: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 2 h / 100 °C / Microwave irradiation

With sodium azide; potassium carbonate; ammonium chloride; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetonitrile;