(+)-Cathinone

Base Information

• Chemical Name: (+)-Cathinone
• CAS No.: 80096-54-4
• Molecular Formula: C9H11NO
• Molecular Weight: 149.192
• UNII: 93UQ761V5A
• DSSTox Substance ID: DTXSID90230076
• Nikkaji Number: J543.577C
• Wikidata: Q27271614
• ChEMBL ID: CHEMBL3301840
• Mol file: 80096-54-4.mol

Synonyms:(+)-Cathinone;Cathinone, (+)-;80096-54-4;1-Propanone, 2-amino-1-phenyl-, (R)-;UNII-93UQ761V5A;BRN 5247016;93UQ761V5A;(R)-(+)-Cathinone;1-Propanone, 2-amino-1-phenyl-, (2R)-;(R)-CATHINONE;CHEMBL3301840;SCHEMBL20095234;DTXSID90230076;LS-122718;Q27271614

Chemical Property of (+)-Cathinone

Chemical Property:

• Vapor Pressure: 0.0167mmHg at 25°C
• Boiling Point: 255°C at 760 mmHg
• Flash Point: 108°C
• Density: 1.054g/cm³
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 149.084063974
• Heavy Atom Count: 11
• Complexity: 139

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C(=O)C1=CC=CC=C1)N
• Isomeric SMILES: C[C@H](C(=O)C1=CC=CC=C1)N

Technology Process of (+)-Cathinone

There total 6 articles about (+)-Cathinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,2R)-(+)-norphedrine (37577-28-9,58550-13-3,757124-50-8) → (R)-β‐ketoamphetamine (80096-54-4)

Guidance literature:

With potassium permanganate;

DOI:10.1002/chir.22048

Reference yield:

(-)-Cathinone hydrochloride (72739-14-1) → cathinone (71031-15-7) + (R)-β‐ketoamphetamine (80096-54-4)

Guidance literature:

With sodium carbonate; In diethyl ether; water; Product distribution; other (-)-α-aminopropiophenone salts, var. solvents and time;

DOI:10.1021/jo00134a026

Reference yield:

(+/-)-cathinone (5265-18-9) → cathinone (71031-15-7) + (R)-β‐ketoamphetamine (80096-54-4)

Guidance literature:

With ammonium formate; In methanol; at 20 ℃; Reagent/catalyst; Solvent; Resolution of racemate;

DOI:10.1002/chir.22985

upstream raw materials:

(+/-)-cathinone

(-)-Cathinone hydrochloride

tert-butyl N-(1-oxo-1-phenylpropan-2-(2R)-yl)carbamate

(1S,2R)-(+)-norphedrine

Downstream raw materials:

(1S,2R)-(+)-norphedrine

Refernces

• 1、 Sehl, Torsten,Hailes, Helen C.,Ward, John M.,Menyes, Ulf,Pohl, Martina,Rother, Doerte. "Efficient 2-step biocatalytic strategies for the synthesis of all nor(pseudo)ephedrine isomers". supporting information. p. 3341 - 3348. Retrieved 2014/06/10.
• 2、 Wolf,Pfander. "Synthesis and structure elucidation of merucathinone and synthesis of cathinone. Constituents of Catha edulis Forsk.". . p. 1498 - 1504. Retrieved 2007/10/02.