72739-14-1

Usage

Uses

Used in Pharmaceutical Industry:
S(-)-CATHINONE HYDROCHLORIDE is used as a research chemical for the development of new medications and therapies. Its psychoactive properties make it a valuable compound for studying the effects of stimulants on the central nervous system and their potential applications in treating various medical conditions.
Used in Forensic Science:
S(-)-CATHINONE HYDROCHLORIDE is utilized as a reference substance in forensic science for the identification and analysis of controlled substances in biological samples, such as blood, urine, and hair. This helps in the detection and monitoring of drug abuse and the enforcement of drug control regulations.
Used in Toxicology Research:
S(-)-CATHINONE HYDROCHLORIDE serves as a valuable tool in toxicology research, where it is used to study the toxic effects of stimulants on various organs and systems in the body. This information is crucial for understanding the risks associated with the use of such substances and for developing strategies to mitigate their harmful effects.
Used in Drug Testing and Analysis:
S(-)-CATHINONE HYDROCHLORIDE is employed as a standard for the calibration of analytical instruments and methods used in drug testing and analysis. This ensures the accuracy and reliability of test results, which is essential for the proper enforcement of drug control measures and the protection of public health.

Upstream product

• 77387-33-8 (1R,2S)-(-)-N-formylnorephedrine 
• 113322-99-9 tert-butyl ((1R,2S)-1-hydroxy-1-phenylpropan-2-yl)carbamate 
• 2114-00-3 2-bromo-1-phenyl-1-propanone 
• 35947-99-0 2-azido-1-phenyl-1-propanone 
• 225098-33-9 tert-butyl ((2S)-1-hydroxy-1-phenylpropan-2-yl)carbamate 
• 108-86-1 bromobenzene 
• 159434-78-3 (-)-(1R,2S)-2-Azido-1-(tert-butyldimethylsiloxy)-1-phenylpropane 
• 79821-73-1 (S)-N-(1-Methyl-2-oxo-2-phenylethyl)carbamidsaeure-(tert-butyl)ester 
• 81626-23-5 (-)-N-formyl-α-aminopropiophenone 
• 53630-90-3 (-)-norephedrine formate 

Downstream Products

• 79821-73-1 (S)-N-(1-Methyl-2-oxo-2-phenylethyl)carbamidsaeure-(tert-butyl)ester 
• 71031-15-7 cathinone 
• 80096-54-4 (R)-β‐ketoamphetamine 

Relevant academic research and scientific papers

A practical synthesis of α-amino ketones via aryllithium addition to N-Boc-α-amino acids

The reaction of N-Boc-α-amino acids with aryllithium reagents followed by removal of the nitrogen protecting group provides enantiomerically pure α-amino aryl ketones as their corresponding HCl salts. This practical two-step sequence gives rapid access to a pharmaceutically interesting class of compounds from commercially available starting materials.

Chiral Phosphoric Acid Catalyzed Enantioselective Synthesis of α-Tertiary Amino Ketones from Sulfonium Ylides

Herein we disclose a new catalytic asymmetric approach for the synthesis of chiral α-Amino ketones, which is particularly useful for the less accessible acyclic α-Tertiary cases. By a protonation-Amination sequence, our approach represents a rare asymmetric H-heteroatom bond insertion by α-carbonyl sulfonium ylides, an attractive surrogate of diazocarbonyls. The mild intermolecular C-N bond formation was catalyzed by chiral phosphoric acids with excellent efficiency and enantioselectivity. The products are precursors to other important chiral amine derivatives, including drug molecules and chiral ligands. The enantioselectivity was controlled by dynamic kinetic resolution in the amination step, rather than the initial protonation. This process opens up a new platform for the development of other related insertion reactions.

Rearrangement of N-tert-butanesulfinyl α-halo imines with alkoxides to N-tert-butanesulfinyl 2-amino acetals as precursors of N-protected and N-unprotected α-amino carbonyl compounds

Reaction of N-tert-butanesulfinyl α-halo imines with alkoxides afforded new N-tert-butanesulfinyl 2-amino acetals in good to excellent yield. These N-tert-butanesulfinyl 2-amino acetals are convenient precursors for the TMSOTf-promoted synthesis of the co

An efficient synthesis of both enantiomers of Cathinone by regioselective reductive ring opening of substituted aziridines

Both enantiomers of Cathinone were prepared as HCl salts from N-(R)-α-methylbenzylaziridine-2(S)-carboxaldehyde 2c and its enantiomer N-(S)-α-methyl-benzylaziridine-2(R)-carboxaldehyde 3c in high yield. This process makes it possible to prepare other aromatic and heteroaromatic analogs of Cathinone efficiently.