N-(3-bromobut-3-en-1-yl)-4-methyl-N-((4-nitrophenyl)ethynyl)benzenesulfonamide

Base Information

Chemical Name:N-(3-bromobut-3-en-1-yl)-4-methyl-N-((4-nitrophenyl)ethynyl)benzenesulfonamide
CAS No.:1361582-91-3
Molecular Formula:C₁₉H₁₇BrN₂O₄S
Molecular Weight:449.325
Hs Code.:

Synonyms:N-(3-bromobut-3-en-1-yl)-4-methyl-N-((4-nitrophenyl)ethynyl)benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-bromobut-3-en-1-yl)-4-methyl-N-((4-nitrophenyl)ethynyl)benzenesulfonamide

Chemical Property:

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Technology Process of N-(3-bromobut-3-en-1-yl)-4-methyl-N-((4-nitrophenyl)ethynyl)benzenesulfonamide

There total 5 articles about N-(3-bromobut-3-en-1-yl)-4-methyl-N-((4-nitrophenyl)ethynyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 591-50-4
iodobenzene

: 1374005-93-2
C₁₃H₁₄BrNO₂S

: 1361582-91-3
N-(3-bromobut-3-en-1-yl)-4-methyl-N-((4-nitrophenyl)ethynyl)benzenesulfonamide

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In toluene; at 20 - 60 ℃; for 1.83333h; Inert atmosphere;
DOI:10.1002/chem.201102880

Reference yield:

: 69116-22-9
1-(iodoethynyl)-4-nitrobenzene

: 1361583-02-9
N-(3-bromobut-3-en-1-yl)-4-methylbenzenesulfonamide

: 1361582-91-3
N-(3-bromobut-3-en-1-yl)-4-methyl-N-((4-nitrophenyl)ethynyl)benzenesulfonamide

Guidance literature:: N-(3-bromobut-3-en-1-yl)-4-methylbenzenesulfonamide; With potassium hexamethylsilazane; phenyl(trimethylsilylethynyl)iodonium triflate; In toluene; at -78 ℃;

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

1-(iodoethynyl)-4-nitrobenzene; With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 60 ℃;
DOI:10.1002/chem.201501710

Reference yield:

: C₁₆H₂₂BrNO₄S

: 1361582-91-3
N-(3-bromobut-3-en-1-yl)-4-methyl-N-((4-nitrophenyl)ethynyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

2.1: potassium hexamethylsilazane / toluene / 0.5 h / -78 - 20 °C / Inert atmosphere

2.2: 18.17 h / -78 - 20 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

4.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / 1.83 h / 20 - 60 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; potassium hexamethylsilazane; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene; 4.1: Sonogashira coupling;
DOI:10.1002/chem.201102880