5-cyclohexyl-7-(4-nitrophenyl)-1-tosyl-2,3,4,5-tetrahydro-1H-indole

Base Information

• Chemical Name: 5-cyclohexyl-7-(4-nitrophenyl)-1-tosyl-2,3,4,5-tetrahydro-1H-indole
• CAS No.: 1361582-56-0
• Molecular Formula: C₂₇H₃₀N₂O₄S
• Molecular Weight: 478.612
• Mol file: 1361582-56-0.mol

Synonyms:5-cyclohexyl-7-(4-nitrophenyl)-1-tosyl-2,3,4,5-tetrahydro-1H-indole

Chemical Property of 5-cyclohexyl-7-(4-nitrophenyl)-1-tosyl-2,3,4,5-tetrahydro-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 5-cyclohexyl-7-(4-nitrophenyl)-1-tosyl-2,3,4,5-tetrahydro-1H-indole

There total 2 articles about 5-cyclohexyl-7-(4-nitrophenyl)-1-tosyl-2,3,4,5-tetrahydro-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(2-cyclohexyl ethenyl)dihydroxy borane (57002-01-4) + N-(3-bromobut-3-en-1-yl)-4-methyl-N-((4-nitrophenyl)ethynyl)benzenesulfonamide (1361582-91-3) → 5-cyclohexyl-7-(4-nitrophenyl)-1-tosyl-2,3,4,5-tetrahydro-1H-indole (1361582-56-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,2-dimethoxyethane; at 85 ℃;

DOI:10.1002/chem.201501710

Reference yield: 74.0%

N-(3-bromobut-3-en-1-yl)-4-methyl-N-((4-nitrophenyl)ethynyl)benzenesulfonamide (1361582-91-3) + (E)-(2-cyclohexylvinyl)boronic acid (57002-01-4,37490-33-8) → 5-cyclohexyl-7-(4-nitrophenyl)-1-tosyl-2,3,4,5-tetrahydro-1H-indole (1361582-56-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,2-dimethoxyethane; for 18h; Reflux; Inert atmosphere;

DOI:10.1002/chem.201102880

upstream raw materials:

N-(3-bromobut-3-en-1-yl)-4-methyl-N-((4-nitrophenyl)ethynyl)benzenesulfonamide

(E)-(2-cyclohexylvinyl)boronic acid

(2-cyclohexyl ethenyl)dihydroxy borane