4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid methyl ester

Base Information

Chemical Name:4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid methyl ester
CAS No.:142599-81-3
Molecular Formula:C₅₀H₄₇N₅O₁₆
Molecular Weight:973.947
Hs Code.:

4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid methyl ester

Synonyms:4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid methyl ester

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Chemical Property of 4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid methyl ester

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Technology Process of 4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid methyl ester

There total 5 articles about 4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 134403-97-7
2-(4-(methoxycarbonyl)-2-nitrophenyl)ethyl chloroformate

: 109205-71-2
2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine

: 142599-81-3
4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid methyl ester

Guidance literature:: With dmap; In dichloromethane; a) 2 h, 0-4 deg C, b) 16 h, room temp.;
DOI:10.1016/S0040-4020(01)92195-7

Reference yield:

: 4-cyanophenylethyl acetate

: 142599-81-3
4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: fuming nitric acid, conc. H₂SO₄ / 2 h / 0 °C

2: 85 percent / HCl (g) / 3 h / Heating

3: 87 percent / CH₂Cl₂; toluene / a) 4 deg C, 30 min, b) room temperature, 3 h

4: 50 percent / DMAP / CH₂Cl₂ / a) 2 h, 0-4 deg C, b) 16 h, room temp.

With hydrogenchloride; dmap; sulfuric acid; nitric acid; In dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)92195-7

Reference yield:

: 69395-13-7
4-(2-hydroxyethyl)benzonitrile

: 142599-81-3
4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: acetic anhydride / 0.5 h / Ambient temperature

2: fuming nitric acid, conc. H₂SO₄ / 2 h / 0 °C

3: 85 percent / HCl (g) / 3 h / Heating

4: 87 percent / CH₂Cl₂; toluene / a) 4 deg C, 30 min, b) room temperature, 3 h

5: 50 percent / DMAP / CH₂Cl₂ / a) 2 h, 0-4 deg C, b) 16 h, room temp.

With hydrogenchloride; dmap; sulfuric acid; nitric acid; In dichloromethane; acetic anhydride; toluene;
DOI:10.1016/S0040-4020(01)92195-7