4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid

Base Information

Chemical Name:4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid
CAS No.:142599-84-6
Molecular Formula:C₄₉H₄₅N₅O₁₆
Molecular Weight:959.92
Hs Code.:

4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid

Synonyms:4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid

There total 6 articles about 4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 142599-81-3
4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid methyl ester

: 142599-84-6
4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; acetonitrile; for 0.0833333h; Ambient temperature;
DOI:10.1016/S0040-4020(01)92195-7

Reference yield:

: 4-cyanophenylethyl acetate

: 142599-84-6
4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: fuming nitric acid, conc. H₂SO₄ / 2 h / 0 °C

2: 85 percent / HCl (g) / 3 h / Heating

3: 87 percent / CH₂Cl₂; toluene / a) 4 deg C, 30 min, b) room temperature, 3 h

4: 50 percent / DMAP / CH₂Cl₂ / a) 2 h, 0-4 deg C, b) 16 h, room temp.

5: 73 percent / 0.05 M aq. NaOH / acetonitrile; dioxane / 0.08 h / Ambient temperature

With hydrogenchloride; dmap; sodium hydroxide; sulfuric acid; nitric acid; In 1,4-dioxane; dichloromethane; toluene; acetonitrile;
DOI:10.1016/S0040-4020(01)92195-7

Reference yield:

: 134403-91-1
methyl 4-(2-hydroxyethyl)-3-nitrobenzoate

: 142599-84-6
4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / CH₂Cl₂; toluene / a) 4 deg C, 30 min, b) room temperature, 3 h

2: 50 percent / DMAP / CH₂Cl₂ / a) 2 h, 0-4 deg C, b) 16 h, room temp.

3: 73 percent / 0.05 M aq. NaOH / acetonitrile; dioxane / 0.08 h / Ambient temperature

With dmap; sodium hydroxide; In 1,4-dioxane; dichloromethane; toluene; acetonitrile;
DOI:10.1016/S0040-4020(01)92195-7