Technology Process of 2-ethyl-3-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}benzaldehyde
There total 9 articles about 2-ethyl-3-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}benzaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium phosphate;
tetrakis(triphenylphosphine) palladium(0);
In
water; N,N-dimethyl-formamide;
at 130 ℃;
for 0.133333h;
Inert atmosphere;
Sealed vessel;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 4 h / -70 - -65 °C
2.1: n-butyllithium; isopropylmagnesium bromide / hexane; tetrahydrofuran / 1.17 h / 0 °C
2.2: 2 h / -10 - 20 °C
2.3: 0.17 h / 0 °C
3.1: hydrogenchloride / water; tetrahydrofuran / 1 h / 20 °C
4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 80 °C
5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 0.13 h / 130 °C / Inert atmosphere; Sealed vessel; Microwave irradiation
With
hydrogenchloride; potassium phosphate; n-butyllithium; isopropylmagnesium bromide; potassium acetate; diisopropylamine;
tetrakis(triphenylphosphine) palladium(0); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
tetrahydrofuran; hexane; water; N,N-dimethyl-formamide;
5.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / tetrahydrofuran / 6.5 h / -10 °C / Inert atmosphere
2.1: sodium hydroxide; water / ethanol / 8 h / 90 °C / Inert atmosphere
3.1: trichlorophosphate / 3 h / 90 °C
3.2: pH ~ 9 / Cooling with ice
4.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 1 h / 0 °C
5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 0.13 h / 130 °C / Inert atmosphere; Sealed vessel; Microwave irradiation
With
potassium phosphate; tert.-butylnitrite; water; sodium hydride; sodium hydroxide; copper(ll) bromide; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
5.1: Suzuki Coupling;
