C₂₇H₂₄F₆N₄O₄

Base Information

• Chemical Name: C₂₇H₂₄F₆N₄O₄
• CAS No.: 1401008-12-5
• Molecular Formula: C₂₇H₂₄F₆N₄O₄
• Molecular Weight: 582.502
• Mol file: 1401008-12-5.mol

Synonyms:C₂₇H₂₄F₆N₄O₄

Chemical Property of C₂₇H₂₄F₆N₄O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₂₄F₆N₄O₄

There total 16 articles about C₂₇H₂₄F₆N₄O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3S,5S,6R)-3-amino-6-methyl-1-(2,2,2-trifluoroethyl)-5-(2,3,5-trifluorophenyl)piperidin-2-one hydrochloride (1375471-09-2) + (4S)-3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-carboxylic acid (1401008-22-7) → C27H24F6N4O4 (1401008-12-5)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

5-bromo-2-hydroxy-6-methylpyridine (54923-31-8) → C27H24F6N4O4 (1401008-12-5)

Guidance literature:

Multi-step reaction with 8 steps

1.1: caesium carbonate / 1,4-dioxane / 4 h / 50 °C

2.1: cesium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

3.1: hydrogen / platinum(IV) oxide / methanol / 2 h / 2327.23 Torr

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 - -65 °C

4.2: 0.75 h / -78 - -65 °C

4.3: -78 - 20 °C

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 760.05 Torr

6.1: potassium carbonate / ethanol / 2 h / 50 °C

7.1: hydrogenchloride / ethyl acetate / 0.5 h

8.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 3 h / 20 °C

With hydrogenchloride; hydrogen; potassium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; cesium fluoride; lithium hexamethyldisilazane; platinum(IV) oxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

(5SR,6RS)-6-methyl-1-(2,2,2-trifluoroethyl)-5-(2,3,5-trifluorophenyl)piperidin-2-one → C27H24F6N4O4 (1401008-12-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 - -65 °C

1.2: 0.75 h / -78 - -65 °C

1.3: -78 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 760.05 Torr

3.1: potassium carbonate / ethanol / 2 h / 50 °C

4.1: hydrogenchloride / ethyl acetate / 0.5 h

5.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 3 h / 20 °C

With hydrogenchloride; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

2-indanone

(+/-)spiro[imidazolidine-4,2'-indane]-2,5-dione

5'-bromo-1',3'-dihydro-2H,5H-spiro[imidazolidine-4,2'-indene]-2,5-dione

5-bromo-2-hydroxy-6-methylpyridine