Technology Process of (3S,5S,6R)-3-amino-6-methyl-1-(2,2,2-trifluoroethyl)-5-(2,3,5-trifluorophenyl)piperidin-2-one hydrochloride
There total 9 articles about (3S,5S,6R)-3-amino-6-methyl-1-(2,2,2-trifluoroethyl)-5-(2,3,5-trifluorophenyl)piperidin-2-one hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
ethyl acetate;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: cesium fluoride / bis(tri-t-butylphosphine)palladium(0) / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere
2.1: hydrogen / platinum(IV) oxide / methanol / 2 h / 2327.23 Torr / Parr hydrogenation apparatus
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 - -65 °C
3.2: 0.75 h / -78 - -65 °C
3.3: -78 - 20 °C
4.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 760.05 Torr
5.1: potassium carbonate / ethanol / 2 h / 50 °C
5.2: Chiralcel.(R). AD column / Resolution of racemate
6.1: hydrogenchloride / ethyl acetate / 0.5 h
With
hydrogenchloride; hydrogen; potassium carbonate; cesium fluoride; lithium hexamethyldisilazane;
platinum(IV) oxide; bis(tri-t-butylphosphine)palladium(0); palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen / platinum(IV) oxide / methanol / 2 h / 2327.23 Torr / Parr hydrogenation apparatus
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 - -65 °C
2.2: 0.75 h / -78 - -65 °C
2.3: -78 - 20 °C
3.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 760.05 Torr
4.1: potassium carbonate / ethanol / 2 h / 50 °C
4.2: Chiralcel.(R). AD column / Resolution of racemate
5.1: hydrogenchloride / ethyl acetate / 0.5 h
With
hydrogenchloride; hydrogen; potassium carbonate; lithium hexamethyldisilazane;
platinum(IV) oxide; palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; ethyl acetate;
![tert-butyl [(3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,5-trifluorophenyl)piperidin-3-yl]carbamate](/Databaselist/images/loading.webp)
