1-(2-((1,4-dimethyl-1H-pyrazol-5-yl)methyl)-4-fluorophenyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine

Base Information

Chemical Name:1-(2-((1,4-dimethyl-1H-pyrazol-5-yl)methyl)-4-fluorophenyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine
CAS No.:1420532-35-9
Molecular Formula:C₂₀H₁₉FN₄
Molecular Weight:334.396
Hs Code.:

Synonyms:1-(2-((1,4-dimethyl-1H-pyrazol-5-yl)methyl)-4-fluorophenyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine

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Chemical Property of 1-(2-((1,4-dimethyl-1H-pyrazol-5-yl)methyl)-4-fluorophenyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(2-((1,4-dimethyl-1H-pyrazol-5-yl)methyl)-4-fluorophenyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine

There total 7 articles about 1-(2-((1,4-dimethyl-1H-pyrazol-5-yl)methyl)-4-fluorophenyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1420532-34-8
5-(2-bromo-5-fluorobenzyl)-1,4-dimethyl-1H-pyrazole

: 824-51-1
6-methyl-1H-pyrrolo<2,3-b>pyridine

: 1420532-35-9
1-(2-((1,4-dimethyl-1H-pyrazol-5-yl)methyl)-4-fluorophenyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: With copper(l) iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; In 1,4-dioxane; at 130 ℃; for 120h; Inert atmosphere;

Reference yield:

: 55052-24-9
1H-Pyrrolo[2,3-b]pyridine-7-oxide

: 1420532-35-9
1-(2-((1,4-dimethyl-1H-pyrazol-5-yl)methyl)-4-fluorophenyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / Inert atmosphere

1.2: 2 h / 20 °C

2.1: methanol; sodium hydroxide / 4 h / 20 °C

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,2-dimethoxyethane / 2 h / 120 °C / Microwave irradiation

4.1: copper(l) iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane / 1,4-dioxane / 120 h / 130 °C / Inert atmosphere

With methanol; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane;

Reference yield:

: 55052-27-2
6-chloro-7-azaindole

: 1420532-35-9
1-(2-((1,4-dimethyl-1H-pyrazol-5-yl)methyl)-4-fluorophenyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,2-dimethoxyethane / 2 h / 120 °C / Microwave irradiation

2: copper(l) iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane / 1,4-dioxane / 120 h / 130 °C / Inert atmosphere

With copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; In 1,4-dioxane; 1,2-dimethoxyethane;