55052-27-2

Basic information

• Product Name: 6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE
• Synonyms: 6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE;6-CHLORO-7-AZAINDOLE;1H-Pyrrolo[2,3-b]pyridine, 6-chloro-;6-chloro-
• CAS NO: 55052-27-2
• Molecular Formula: C₇H₅ClN₂
• Molecular Weight: 152.58
• EINECS: 1533716-785-6
• Product Categories: Pyridines
• Mol File: 55052-27-2.mol
• Article Data: 13

Chemical Properties

• Melting Point: 170-175℃
• Boiling Point: 304.9 °C at 760 mmHg
• Flash Point: 166.8 °C
• Appearance: White to pale brown/Powder
• Density: 1.425 g/cm³
• Vapor Pressure: 0.00153mmHg at 25°C
• Refractive Index: 1.703
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 6.76±0.40(Predicted)
• CAS DataBase Reference: 6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE(55052-27-2)
• EPA Substance Registry System: 6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE(55052-27-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• RIDADR: UN2811
• HazardClass: 6.1
• Hazardous Substances Data: 55052-27-2(Hazardous Substances Data)

Usage

Uses

6-Chloro-1H-pyrrolo[2,3-b]pyridine is used in the preparation of heterocyclic compounds for the use of treatment of cancer.

InChI:InChI=1/C7H5ClN2/c8-6-2-1-5-3-4-9-7(5)10-6/h1-4H,(H,9,10)

Upstream product

• 272-49-1 1H-pyrrolo[3,2-b]pyridine 
• 271-63-6 7-Azaindole 
• 849068-50-4 ethyl 6-chloro-1H-pyrrolo[2,3-b]pyridine-1-carboxylate 
• 55052-24-9 1H-Pyrrolo[2,3-b]pyridine-7-oxide 
• 143468-11-5 1-Benzoyl-6-chloro-1H-pyrrolo<2,3-b>pyridine 
• 143468-07-9 6-Chloro-1-methoxycarbonyl-1H-pyrrolo<2,3-b>pyridine 

Downstream Products

• 351438-94-3 6-phenyl-1H-pyrrolo[2,3-b]pyridine 
• 383875-59-0 6-chloro-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde 
• 1248587-69-0 N-(3-fluorophenyl)-N-methyl-1H-pyrrolo[2,3-b]pyridin-6-amine 
• 934568-25-9 6-chloro-1-methyl-1H-pyrrolo[2,3-b]pyridine 
• 145901-11-7 6-amino-1H-pyrrolo<2,3-b>pyridine 
• 824-51-1 6-methyl-1H-pyrrolo<2,3-b>pyridine 
• 1420532-48-4 ?tert-butyl 2-(1-(2-((3,5-dimethyl-4H-1,2,4-triazol-4-yl)methyl)-4-methylphenyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetate 
• 1420532-47-3 tert-butyl 2-(1-(2-(ethanethioamidomethyl)-4-methylphenyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetate 
• 1420532-46-2 tert-butyl 2-(1-(2-(acetamidomethyl)-4-methylphenyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetate 
• 1000340-28-2 3-bromo-6-methyl-1H-pyrrolo[2,3-b]pyridine 
• 1420532-35-9 1-(2-((1,4-dimethyl-1H-pyrazol-5-yl)methyl)-4-fluorophenyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine 
• 1420532-29-1 (5-bromo-2-(6-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)phenyl)methanamine 
• 1420532-28-0 5-bromo-2-(6-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)benzonitrile 
• 1346151-47-0 6-methyl-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES

The invention relates to compounds of formula (II) for using in imaging and particularly for the diagnosis of neurodegenerative diseases

Preparation method of drug composition for treating febrile convulsion in children

The invention relates to a preparation method of a drug composition for treating febrile convulsion in children. The method comprises a route as shown in the specification. A treatment mechanism of the drug of the invention is to prolong the convulsion latency of a febrile convulsion patient, shorten the convulsion duration, relieve the convulsion seriousness, inhibit apoptosis of hippocampal neurons, regulate the levels of GABA and Glu, relieve the cerebral injury of febrile convulsion patient and finally achieve the purpose of treating the febrile convulsion.

Synthetic method of 6-chloro-7-azaindole

The invention discloses a synthetic method of 6-chloro-7-azaindole, belonging to the field of chemical synthesis. 7-azaindole is taken as a raw material, and the 6-chloro-7-azaindole is synthesized by three actions of N-oxidation, chlorination and hydrolysis. The process route is optimized, and the yield is improved by 70% or more, and is improved by 7% compared with the prior art. The improved synthetic route is simple to operate and feasible, the economic benefits are effectively improved, and large-scale industrial promotion is facilitated.