C₂₃H₂₀F₃NO₃

Base Information

Chemical Name:C₂₃H₂₀F₃NO₃
CAS No.:1427406-48-1
Molecular Formula:C₂₃H₂₀F₃NO₃
Molecular Weight:415.412
Hs Code.:

C<sub>23</sub>H<sub>20</sub>F<sub>3</sub>NO<sub>3</sub>

Synonyms:C₂₃H₂₀F₃NO₃

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Chemical Property of C₂₃H₂₀F₃NO₃

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Technology Process of C₂₃H₂₀F₃NO₃

There total 14 articles about C₂₃H₂₀F₃NO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1427408-01-2
C₂₆H₂₆F₃NO₃

: 1427406-48-1
C₂₃H₂₀F₃NO₃

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; for 2h;

Reference yield:

: 1227210-35-6
1-bromo-4-fluoro-2-methyl-3-nitro-benzene

: 1427406-48-1
C₂₃H₂₀F₃NO₃

Guidance literature:: Multi-step reaction with 9 steps

1.1: iron; ammonium chloride / ethanol / 3 h / Reflux

2.1: dmap; triethylamine / N,N-dimethyl-formamide

3.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 4 h / 80 °C / Inert atmosphere

4.1: dihydrogen peroxide; water; sodium hydroxide / tetrahydrofuran / 3 h / 0 - 20 °C

5.1: trifluoroacetic acid / dichloromethane / 20 °C

6.1: potassium carbonate / tetrahydrofuran / 3 h / 0 - 20 °C

7.1: borane-THF / tetrahydrofuran / 60 °C

8.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

8.2: 1 h

9.1: water; sodium hydroxide / tetrahydrofuran / 2 h

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; borane-THF; water; dihydrogen peroxide; potassium acetate; iron; potassium carbonate; ammonium chloride; caesium carbonate; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 3013-27-2
1-fluoro-3-methyl-2-nitro-benzene

: 1427406-48-1
C₂₃H₂₀F₃NO₃

Guidance literature:: Multi-step reaction with 10 steps

1.1: sulfuric acid; N-Bromosuccinimide / 2 h / 20 °C

2.1: iron; ammonium chloride / ethanol / 3 h / Reflux

3.1: dmap; triethylamine / N,N-dimethyl-formamide

4.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 4 h / 80 °C / Inert atmosphere

5.1: dihydrogen peroxide; water; sodium hydroxide / tetrahydrofuran / 3 h / 0 - 20 °C

6.1: trifluoroacetic acid / dichloromethane / 20 °C

7.1: potassium carbonate / tetrahydrofuran / 3 h / 0 - 20 °C

8.1: borane-THF / tetrahydrofuran / 60 °C

9.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

9.2: 1 h

10.1: water; sodium hydroxide / tetrahydrofuran / 2 h

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; borane-THF; sulfuric acid; water; dihydrogen peroxide; potassium acetate; iron; potassium carbonate; ammonium chloride; caesium carbonate; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;