3-(tert-butyldimethylsilyloxy)-4-(p-methoxybenzyloxy)-2-methylenebutanoic acid

Base Information

Chemical Name:3-(tert-butyldimethylsilyloxy)-4-(p-methoxybenzyloxy)-2-methylenebutanoic acid
CAS No.:1222854-23-0
Molecular Formula:C₁₉H₃₀O₅Si
Molecular Weight:366.53
Hs Code.:

Synonyms:3-(tert-butyldimethylsilyloxy)-4-(p-methoxybenzyloxy)-2-methylenebutanoic acid

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Chemical Property of 3-(tert-butyldimethylsilyloxy)-4-(p-methoxybenzyloxy)-2-methylenebutanoic acid

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Technology Process of 3-(tert-butyldimethylsilyloxy)-4-(p-methoxybenzyloxy)-2-methylenebutanoic acid

There total 5 articles about 3-(tert-butyldimethylsilyloxy)-4-(p-methoxybenzyloxy)-2-methylenebutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1222854-21-8
methyl 3-{[t-butyl(dimethyl)silyl]oxy}-4-(p-methoxybenzyloxy)-2-methylenebutanoate

: 1222854-23-0
3-(tert-butyldimethylsilyloxy)-4-(p-methoxybenzyloxy)-2-methylenebutanoic acid

Guidance literature:: methyl 3-(tert-butyldimethylsilyloxy)-4-(p-methoxybenzyloxy)-2-methylenebutanoate; With lithium hydroxide monohydrate; water; In acetonitrile; at 55 ℃; for 1h;

With hydrogenchloride; In water; acetonitrile; pH=3;
DOI:10.1016/j.phytochem.2009.10.008

Reference yield:

: 1222854-19-4
(S)-methyl 3-hydroxy-4-((4-methoxybenzyl)oxy)-2-methylenebutanoate

: 1222854-23-0
3-(tert-butyldimethylsilyloxy)-4-(p-methoxybenzyloxy)-2-methylenebutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane

2: lithium hydroxide / water; acetonitrile / 60 °C

With triethylamine; lithium hydroxide; In dichloromethane; water; acetonitrile;
DOI:10.1271/bbb.100845

Reference yield:

: 1314920-22-3
(6S)-2,6-di((p-methoxybenzyloxy)methyl)-5-methylene-1,3-dioxan-4-one

: 1222854-23-0
3-(tert-butyldimethylsilyloxy)-4-(p-methoxybenzyloxy)-2-methylenebutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine

2: triethylamine / dichloromethane

3: lithium hydroxide / water; acetonitrile / 60 °C

With triethylamine; lithium hydroxide; In dichloromethane; water; acetonitrile;
DOI:10.1271/bbb.100845