methyl 3-{[t-butyl(dimethyl)silyl]oxy}-4-(p-methoxybenzyloxy)-2-methylenebutanoate

Base Information

Chemical Name:methyl 3-{[t-butyl(dimethyl)silyl]oxy}-4-(p-methoxybenzyloxy)-2-methylenebutanoate
CAS No.:1222854-21-8
Molecular Formula:C₂₀H₃₂O₅Si
Molecular Weight:380.557
Hs Code.:

Synonyms:methyl 3-{[t-butyl(dimethyl)silyl]oxy}-4-(p-methoxybenzyloxy)-2-methylenebutanoate

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Chemical Property of methyl 3-{[t-butyl(dimethyl)silyl]oxy}-4-(p-methoxybenzyloxy)-2-methylenebutanoate

Chemical Property:

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Technology Process of methyl 3-{[t-butyl(dimethyl)silyl]oxy}-4-(p-methoxybenzyloxy)-2-methylenebutanoate

There total 3 articles about methyl 3-{[t-butyl(dimethyl)silyl]oxy}-4-(p-methoxybenzyloxy)-2-methylenebutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1222854-19-4
(S)-methyl 3-hydroxy-4-((4-methoxybenzyl)oxy)-2-methylenebutanoate

: 69739-34-0
t-butyldimethylsiyl triflate

: 1222854-21-8
methyl 3-{[t-butyl(dimethyl)silyl]oxy}-4-(p-methoxybenzyloxy)-2-methylenebutanoate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.phytochem.2009.10.008

Reference yield:

: 121289-23-4
p-methoxybenzyloxyacetaldehyde

: 1222854-21-8
methyl 3-{[t-butyl(dimethyl)silyl]oxy}-4-(p-methoxybenzyloxy)-2-methylenebutanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,4-diaza-bicyclo[2.2.2]octane / N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 120 h / 0 °C

2.1: triethylamine

3.1: triethylamine / dichloromethane

With 1,4-diaza-bicyclo[2.2.2]octane; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1271/bbb.100845

Reference yield:

: methyl 3-hydroxy-4-((4-methoxybenzyl)oxy)-2-methylenebutanoate

: 1222854-21-8
methyl 3-{[t-butyl(dimethyl)silyl]oxy}-4-(p-methoxybenzyloxy)-2-methylenebutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: titanium(IV) isopropylate; tert.-butylhydroperoxide / dichloromethane / -20 °C

2: triethylamine / dichloromethane / 0 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; triethylamine; In dichloromethane;
DOI:10.3987/COM-21-14562