guanosine 5'-(tetrahydrogen triphosphate)

Base Information

• Chemical Name: guanosine 5'-(tetrahydrogen triphosphate)
• CAS No.: 86-01-1
• Molecular Formula: C10H16 N5 O14 P3
• Molecular Weight: 523.183
• Mol file: 86-01-1.mol

Synonyms:Guanosinetriphosphate (6CI); 5'-GTP; GTP; Guanosine 5'-triphosphate; Guanosine5'-triphosphoric acid; Guanosine, mono(tetrahydrogen triphosphate) (ester)

Chemical Property of guanosine 5'-(tetrahydrogen triphosphate)

Chemical Property:

• Boiling Point: 1028.3oC at 760 mmHg
• PKA: pK3:3.0(－2);pk5:7.10(－3);pK6:9.3(－4) (25°C,μ=0.1)
• Flash Point: 575.7oC
• PSA: 328.53000
• Density: 2.75g/cm3
• LogP: -1.75450

Purity/Quality:

99%, ^*data from raw suppliers

GTP 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Guanosine 5''-Triphosphate is used in studying the mechanism of action of selected nucleotide analogs. It is used in the screening or evaluating nucleotide-?based drugs targeting SARS-?CoV-?2 RdRp.

Technology Process of guanosine 5'-(tetrahydrogen triphosphate)

There total 29 articles about guanosine 5'-(tetrahydrogen triphosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

Guanosine 5'-monophosphate (85-32-5) → guanosine-5'-diphosphate (146-91-8) + Guanosine 5'-triphosphate (86-01-1,72490-81-4)

Guidance literature:

With phosphorotriimidazolide; magnesium chloride; at 22 ℃; for 72h; N-ethylmorpholine buffer (pH 7.0);

DOI:10.1016/S0040-4039(00)74092-5

Reference yield: 12.0%

C10H15N5O15P4 → Guanosine 5'-triphosphate (86-01-1,72490-81-4)

Guidance literature:

With pyridine; water; iodine; In N,N-dimethyl-formamide; at 20 ℃; for 2.25h;

Reference yield:

→ guanosine 5'-triphosphate (86-01-1) + cytidine triphosphate (65-47-4,13191-15-6) + UTP (63-39-8) + ATP (56-65-5,896506-78-8)

Guidance literature:

With sodium hydroxide; potassium phosphate; nuclease P₁; PAN-immobilized PNPase; phospho(enol)pyruvic acid mono potassium salt; magnesium chloride; manganese(ll) chloride; Yield given. Multistep reaction. Yields of byproduct given; 1.) water, 50 deg C, 1 h, 2.) room temperature, 4 days;

DOI:10.1021/ja00339a021

upstream raw materials:

Guanosine 5'-monophosphate

phosphoenolpyruvic acid

guanosine-5'-diphosphate

guanosine 5'-monophosphate disodium

Downstream raw materials:

guanosine-5'-diphosphate

G

glyceric acid 1,3-biphosphate

bis-(3′,5′)-cyclic dimeric guanosine monophosphate

Refernces

• 1、 -. "Synthetic method of nucleoside tetraphosphate". . . Retrieved 2019/02/04.
• 2、 Reimao-Pinto, Madalena M.,Cordeiro, Ana,Almeida, Carina,Pinheiro, Andre V.,Moro, Artur,Lima, Joao C.,Baptista, Pedro V.. "Dual-color control of nucleotide polymerization sensed by a fluorescence actuator". . p. 751 - 756. Retrieved 2014/05/06.