(2R)-N-{4-[2-({4-[(3-fluoroazetidin-1-yl)carbonyl]-2-methoxyphenyl}amino)-[1,2,4]triazolo[1,5-α]pyridin-6-yl]phenyl}-2-(4-fluorophenyl)propanamide

Base Information

• Chemical Name: (2R)-N-{4-[2-({4-[(3-fluoroazetidin-1-yl)carbonyl]-2-methoxyphenyl}amino)-[1,2,4]triazolo[1,5-α]pyridin-6-yl]phenyl}-2-(4-fluorophenyl)propanamide
• CAS No.: 1443763-66-3
• Molecular Formula: C₃₂H₂₈F₂N₆O₃
• Molecular Weight: 582.61
• Mol file: 1443763-66-3.mol

Synonyms:(2R)-N-{4-[2-({4-[(3-fluoroazetidin-1-yl)carbonyl]-2-methoxyphenyl}amino)-[1,2,4]triazolo[1,5-α]pyridin-6-yl]phenyl}-2-(4-fluorophenyl)propanamide

Chemical Property of (2R)-N-{4-[2-({4-[(3-fluoroazetidin-1-yl)carbonyl]-2-methoxyphenyl}amino)-[1,2,4]triazolo[1,5-α]pyridin-6-yl]phenyl}-2-(4-fluorophenyl)propanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-N-{4-[2-({4-[(3-fluoroazetidin-1-yl)carbonyl]-2-methoxyphenyl}amino)-[1,2,4]triazolo[1,5-α]pyridin-6-yl]phenyl}-2-(4-fluorophenyl)propanamide

There total 21 articles about (2R)-N-{4-[2-({4-[(3-fluoroazetidin-1-yl)carbonyl]-2-methoxyphenyl}amino)-[1,2,4]triazolo[1,5-α]pyridin-6-yl]phenyl}-2-(4-fluorophenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluorobenzeneacetic acid methyl ester (34837-84-8) → (2R)-N-{4-[2-({4-[(3-fluoroazetidin-1-yl)carbonyl]-2-methoxyphenyl}amino)-[1,2,4]triazolo[1,5-α]pyridin-6-yl]phenyl}-2-(4-fluorophenyl)propanamide (1443763-66-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 1 h / -78 - 0 °C

2.1: potassium hydroxide; water / ethanol / 4 h / 0 °C

3.1: ethyl acetate / Reflux

4.1: sodium hydrogencarbonate; HATU / dichloromethane; N,N-dimethyl-formamide / 4 h / 20 °C

With water; sodium hydrogencarbonate; HATU; potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

(4-{[6-(4-aminophenyl)[1,2,4]triazolo[1,5-α]pyridin-2-yl]amino}-3-methoxyphenyl)(3-fluoroazetidin-1-yl)methanone (1443763-99-2) + (2R)-2-(4-fluorophenyl)propanoic acid (150360-26-2) → (2R)-N-{4-[2-({4-[(3-fluoroazetidin-1-yl)carbonyl]-2-methoxyphenyl}amino)-[1,2,4]triazolo[1,5-α]pyridin-6-yl]phenyl}-2-(4-fluorophenyl)propanamide (1443763-66-3)

Guidance literature:

With sodium hydrogencarbonate; HATU; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

(4-bromo-3-methoxyphenyl)(pyrrolidin-1-yl)methanone (876752-72-6) + {4-[(6-chloro[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino]-3-methoxyphenyl}(3-fluoroazetidin-1-yl)methanone (1539264-94-2) → (2R)-N-{4-[2-({4-[(3-fluoroazetidin-1-yl)carbonyl]-2-methoxyphenyl}amino)-[1,2,4]triazolo[1,5-α]pyridin-6-yl]phenyl}-2-(4-fluorophenyl)propanamide (1443763-66-3)

Guidance literature:

With potassium fluoride; potassium phosphate monohydrate; dicyclohexyl(2',6'-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine; palladium diacetate; In toluene; for 2h; Inert atmosphere; Reflux;

upstream raw materials:

4-fluorobenzeneacetic acid methyl ester

ethyl [(5-bromopyridin-2-yl)carbamothioyl]carbamate

methyl 2-(4-fluorophenyl)propanoate

(4-{[6-(4-aminophenyl)[1,2,4]triazolo[1,5-α]pyridin-2-yl]amino}-3-methoxyphenyl)(3-fluoroazetidin-1-yl)methanone