6,7-difluoro-1-hydroxy-2-phenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylicacid ethyl ester

Base Information

Chemical Name:6,7-difluoro-1-hydroxy-2-phenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylicacid ethyl ester
CAS No.:346687-19-2
Molecular Formula:C₁₈H₁₃F₂NO₄
Molecular Weight:345.302
Hs Code.:

Synonyms:6,7-difluoro-1-hydroxy-2-phenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylicacid ethyl ester

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Chemical Property of 6,7-difluoro-1-hydroxy-2-phenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylicacid ethyl ester

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Technology Process of 6,7-difluoro-1-hydroxy-2-phenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylicacid ethyl ester

There total 4 articles about 6,7-difluoro-1-hydroxy-2-phenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylicacid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: ethyl 2-benzoyl-3-(4,5-difluoro-2-nitrophenyl)-3-oxopropanoate

: 346687-19-2
6,7-difluoro-1-hydroxy-2-phenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylicacid ethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 6h; under 760 Torr;
DOI:10.1002/jhet.5570380109

Reference yield:

: 455-86-7
3,4-Difluorobenzoic acid

: 346687-19-2
6,7-difluoro-1-hydroxy-2-phenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylicacid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 86 percent / HNO₃; H₂SO₄ / 4 h / 10 - 20 °C

2.1: SOCl₂; urea / toluene / 3 h / 100 °C

3.1: Mg; EtOH / CCl₄; toluene / 2 h

3.2: toluene; CCl₄ / 0.5 h / 20 °C

4.1: 71 percent / H₂ / 10 percent Pd/C / ethanol / 3 h / 20 °C

With thionyl chloride; ethanol; sulfuric acid; hydrogen; nitric acid; magnesium; urea; palladium on activated charcoal; In tetrachloromethane; ethanol; toluene;

Reference yield:

: 20372-63-8
4,5-difluoro-2-nitrobenzoic acid

: 346687-19-2
6,7-difluoro-1-hydroxy-2-phenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylicacid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: SOCl₂; urea / toluene / 3 h / 100 °C

2.1: Mg; EtOH / CCl₄; toluene / 2 h

2.2: toluene; CCl₄ / 0.5 h / 20 °C

3.1: 71 percent / H₂ / 10 percent Pd/C / ethanol / 3 h / 20 °C

With thionyl chloride; ethanol; hydrogen; magnesium; urea; palladium on activated charcoal; In tetrachloromethane; ethanol; toluene;