3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]propyl butylcarbamate

Base Information

Chemical Name:3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]propyl butylcarbamate
CAS No.:926299-22-1
Molecular Formula:C₂₃H₂₈ClF₃N₂O₅
Molecular Weight:504.934
Hs Code.:

Synonyms:3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]propyl butylcarbamate

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Chemical Property of 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]propyl butylcarbamate

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Technology Process of 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]propyl butylcarbamate

There total 6 articles about 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]propyl butylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 888740-24-7
3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]propan-1-ol

: 109-73-9,85404-21-3
N-butylamine

: 530-62-1
1,1'-carbonyldiimidazole

: 926299-22-1
3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]propyl butylcarbamate

Guidance literature:: 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]propan-1-ol; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 60 ℃; for 1h;

N-butylamine; In N,N-dimethyl-formamide; at 20 ℃; for 6h;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 888740-23-6
ethyl 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]propanoate

: 926299-22-1
3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]propyl butylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.17 h / 0 °C

1.2: 0 °C

2.1: N,N-dimethyl-formamide / 1 h / 60 °C

2.2: 6 h / 20 °C

With diisobutylaluminium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 888740-62-3
ethyl (2E)-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(methoxymethoxy)phenyl]acrylate

: 926299-22-1
3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]propyl butylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 1 h / 20 °C / 760.05 Torr

2.1: hydrogenchloride; water / tetrahydrofuran / 0.75 h / 50 °C

3.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 0.08 h / 50 °C

4.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.17 h / 0 °C

4.2: 0 °C

5.1: N,N-dimethyl-formamide / 1 h / 60 °C

5.2: 6 h / 20 °C

With hydrogenchloride; tributylphosphine; palladium 10% on activated carbon; water; hydrogen; diisobutylaluminium hydride; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 3.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2012.03.036