methyl (2S)-2-(2-(4-bromophenyl)-3-(tert-butoxycarbonylamino)tetrahydrofuran-3-carboxamido)-3-methylbutanoate

Base Information

• Chemical Name: methyl (2S)-2-(2-(4-bromophenyl)-3-(tert-butoxycarbonylamino)tetrahydrofuran-3-carboxamido)-3-methylbutanoate
• CAS No.: 1149669-81-7
• Molecular Formula: C₂₂H₃₁BrN₂O₆
• Molecular Weight: 499.402

Synonyms:methyl (2S)-2-(2-(4-bromophenyl)-3-(tert-butoxycarbonylamino)tetrahydrofuran-3-carboxamido)-3-methylbutanoate

Chemical Property of methyl (2S)-2-(2-(4-bromophenyl)-3-(tert-butoxycarbonylamino)tetrahydrofuran-3-carboxamido)-3-methylbutanoate

Chemical Property:

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Technology Process of methyl (2S)-2-(2-(4-bromophenyl)-3-(tert-butoxycarbonylamino)tetrahydrofuran-3-carboxamido)-3-methylbutanoate

There total 1 articles about methyl (2S)-2-(2-(4-bromophenyl)-3-(tert-butoxycarbonylamino)tetrahydrofuran-3-carboxamido)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H20BrNO5 + L-valine methylester hydrochloride (6306-52-1) → methyl (2S)-2-(2-(4-bromophenyl)-3-(tert-butoxycarbonylamino)tetrahydrofuran-3-carboxamido)-3-methylbutanoate (1149669-84-0) + methyl (2S)-2-(2-(4-bromophenyl)-3-(tert-butoxycarbonylamino)tetrahydrofuran-3-carboxamido)-3-methylbutanoate (1149669-81-7)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jo900222g

Reference yield: 100.0%

methyl (2S)-2-(2-(4-bromophenyl)-3-(tert-butoxycarbonylamino)tetrahydrofuran-3-carboxamido)-3-methylbutanoate (1149669-81-7) → C17H23BrN2O4*ClH

Guidance literature:

With hydrogenchloride; In diethyl ether; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jo900222g

Reference yield: 93.0%

methyl (2S)-2-(2-(4-bromophenyl)-3-(tert-butoxycarbonylamino)tetrahydrofuran-3-carboxamido)-3-methylbutanoate (1149669-81-7) → (S)-2-((2S,3R)-2-(4-bromophenyl)-3-(tert-butoxycarbonylamino)tetrahydrofuran-3-carboxamido)-3-methylbutanoic acid (1149669-99-7)

Guidance literature:

With lithium hydroxide; water; In acetonitrile; at 20 ℃; Inert atmosphere;

DOI:10.1021/jo900222g

upstream raw materials:

L-valine methylester hydrochloride

Downstream raw materials:

(S)-2-((2S,3R)-2-(4-bromophenyl)-3-(tert-butoxycarbonylamino)tetrahydrofuran-3-carboxamido)-3-methylbutanoic acid

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