(E)-(1S,5R,5(2S))-5-<<5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>methyl>-3-<<1-(phenylmethyl)-1H-imidazol-5-yl>methylene>cyclohexaneacetamide

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Chemical Name:(E)-(1S,5R,5(2S))-5-<<5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>methyl>-3-<<1-(phenylmethyl)-1H-imidazol-5-yl>methylene>cyclohexaneacetamide
CAS No.:131879-77-1
Molecular Formula:C₃₁H₃₆N₄O₂
Molecular Weight:496.652
Hs Code.:

Synonyms:(E)-(1S,5R,5(2S))-5-<<5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>methyl>-3-<<1-(phenylmethyl)-1H-imidazol-5-yl>methylene>cyclohexaneacetamide

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Chemical Property of (E)-(1S,5R,5(2S))-5-<<5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>methyl>-3-<<1-(phenylmethyl)-1H-imidazol-5-yl>methylene>cyclohexaneacetamide

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Technology Process of (E)-(1S,5R,5(2S))-5-<<5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>methyl>-3-<<1-(phenylmethyl)-1H-imidazol-5-yl>methylene>cyclohexaneacetamide

There total 6 articles about (E)-(1S,5R,5(2S))-5-<<5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>methyl>-3-<<1-(phenylmethyl)-1H-imidazol-5-yl>methylene>cyclohexaneacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 131879-99-7
(5S-5(2S))-3-oxo-5-<<5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>methyl>-1-cyclohexene-1-acetic acid ethyl ester

: 131879-77-1
(E)-(1S,5R,5(2S))-5-<<5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>methyl>-3-<<1-(phenylmethyl)-1H-imidazol-5-yl>methylene>cyclohexaneacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 7.8 g / H₂ / 10percent Pd/C / ethanol / 3 h / 2585.7 Torr

2: 1.) LDA / 1.) ether, hexane, THF, from -15 to -20 deg C, 0.5 h, 2.) ether, hexane, THF, a.) -15 deg C, 15 min, b.) 0 deg C, 2.5 h

3: 1.) benzylamine / 1.) MeOH, RT, 1 h, 2.) MeOH, RT, overnight

4: KOH / ethanol / 0.5 h / 75 °C

5: 1.) ethyl chloroformate,, Et₃N, 2.) NH₃(gas) / 1.) CHCl₃, 0 deg C, 30 min, 2.) CHCl₃, RT, 2 h

With potassium hydroxide; ammonia; hydrogen; chloroformic acid ethyl ester; triethylamine; benzylamine; lithium diisopropyl amide; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00015a009

Reference yield:

: 79782-60-8
<2-<(phenylmethyl)amino>ethenyl>phosphonic acid diethyl ester

: 131879-77-1
(E)-(1S,5R,5(2S))-5-<<5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>methyl>-3-<<1-(phenylmethyl)-1H-imidazol-5-yl>methylene>cyclohexaneacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LDA / 1.) ether, hexane, THF, from -15 to -20 deg C, 0.5 h, 2.) ether, hexane, THF, a.) -15 deg C, 15 min, b.) 0 deg C, 2.5 h

2: 1.) benzylamine / 1.) MeOH, RT, 1 h, 2.) MeOH, RT, overnight

3: KOH / ethanol / 0.5 h / 75 °C

4: 1.) ethyl chloroformate,, Et₃N, 2.) NH₃(gas) / 1.) CHCl₃, 0 deg C, 30 min, 2.) CHCl₃, RT, 2 h

With potassium hydroxide; ammonia; chloroformic acid ethyl ester; triethylamine; benzylamine; lithium diisopropyl amide; In ethanol;
DOI:10.1021/jm00015a009

Reference yield:

: 131880-00-7
(1S,5S,5(2S))-3-oxo-5-<<5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>methyl>-cyclohexaneacetic acid ethyl ester

: 131879-77-1
(E)-(1S,5R,5(2S))-5-<<5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>methyl>-3-<<1-(phenylmethyl)-1H-imidazol-5-yl>methylene>cyclohexaneacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LDA / 1.) ether, hexane, THF, from -15 to -20 deg C, 0.5 h, 2.) ether, hexane, THF, a.) -15 deg C, 15 min, b.) 0 deg C, 2.5 h

2: 1.) benzylamine / 1.) MeOH, RT, 1 h, 2.) MeOH, RT, overnight

3: KOH / ethanol / 0.5 h / 75 °C

4: 1.) ethyl chloroformate,, Et₃N, 2.) NH₃(gas) / 1.) CHCl₃, 0 deg C, 30 min, 2.) CHCl₃, RT, 2 h

With potassium hydroxide; ammonia; chloroformic acid ethyl ester; triethylamine; benzylamine; lithium diisopropyl amide; In ethanol;
DOI:10.1021/jm00015a009