ethyl <3--2-oxopropyl>(cyclohexylmethyl)phosphinate

Base Information

Chemical Name:ethyl <3--2-oxopropyl>(cyclohexylmethyl)phosphinate
CAS No.:133457-84-8
Molecular Formula:C₁₇H₃₂NO₅P
Molecular Weight:361.419
Hs Code.:

ethyl <3-<N-(tert-butoxycarbonyl)amino>-2-oxopropyl>(cyclohexylmethyl)phosphinate

Synonyms:ethyl <3--2-oxopropyl>(cyclohexylmethyl)phosphinate

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Chemical Property of ethyl <3--2-oxopropyl>(cyclohexylmethyl)phosphinate

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Technology Process of ethyl <3--2-oxopropyl>(cyclohexylmethyl)phosphinate

There total 3 articles about ethyl <3--2-oxopropyl>(cyclohexylmethyl)phosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31954-27-5
N-(tert-butoxycarbonyl)glycine methyl ester

: 133457-83-7
ethyl (cyclohexylmethyl)methylphosphinate

: 133457-84-8
ethyl <3--2-oxopropyl>(cyclohexylmethyl)phosphinate

Guidance literature:: With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C, 15 min;
DOI:10.1021/jm00017a016

Reference yield:

: 153994-66-2
1,1-diethoxyethyl(cyclohexylmethyl)phosphinic acid ethyl ester

: 133457-84-8
ethyl <3--2-oxopropyl>(cyclohexylmethyl)phosphinate

Guidance literature:: Multi-step reaction with 3 steps

1: trimethylsilyl chloride / CH₂Cl₂ / 24 h / Ambient temperature

2: 1.) NaH / 1.) THF, RT, 3 h, 2.) RT, 24 h

3: 1.) LDA / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C, 15 min

With chloro-trimethyl-silane; sodium hydride; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/jm00017a016

Reference yield:

: 133457-82-6
P-(cyclohexylmethyl)phosphinic acid ethyl ester

: 133457-84-8
ethyl <3--2-oxopropyl>(cyclohexylmethyl)phosphinate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) THF, RT, 3 h, 2.) RT, 24 h

2: 1.) LDA / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C, 15 min

With sodium hydride; lithium diisopropyl amide;
DOI:10.1021/jm00017a016