2-[1-(2,5-Dimethoxy-phenyl)-1-methoxy-ethyl]-2-trimethylsilanyloxy-cyclobutanone

Base Information

Chemical Name:2-[1-(2,5-Dimethoxy-phenyl)-1-methoxy-ethyl]-2-trimethylsilanyloxy-cyclobutanone
CAS No.:72229-48-2
Molecular Formula:C₁₈H₂₈O₅Si
Molecular Weight:352.503
Hs Code.:

Synonyms:2-[1-(2,5-Dimethoxy-phenyl)-1-methoxy-ethyl]-2-trimethylsilanyloxy-cyclobutanone

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Chemical Property of 2-[1-(2,5-Dimethoxy-phenyl)-1-methoxy-ethyl]-2-trimethylsilanyloxy-cyclobutanone

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Technology Process of 2-[1-(2,5-Dimethoxy-phenyl)-1-methoxy-ethyl]-2-trimethylsilanyloxy-cyclobutanone

There total 3 articles about 2-[1-(2,5-Dimethoxy-phenyl)-1-methoxy-ethyl]-2-trimethylsilanyloxy-cyclobutanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 17082-61-0
1,2-bis(trimethylsiloxy)cyclobutene

: 72229-44-8
2',5'-dimethoxyacetophenone dimethyl acetal

: 72229-54-0
2-methyl-2-(2',5'-dimethoxyphenyl)cyclopentane-1,3-dione

: 72229-48-2
2-[1-(2,5-Dimethoxy-phenyl)-1-methoxy-ethyl]-2-trimethylsilanyloxy-cyclobutanone

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at -78 ℃; for 4h;
DOI:10.1021/jo01291a026

Reference yield:

: 1201-38-3
2',5'-dimethoxyacetophenone

: 72229-48-2
2-[1-(2,5-Dimethoxy-phenyl)-1-methoxy-ethyl]-2-trimethylsilanyloxy-cyclobutanone

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / p-toluenesulfonic acid / methanol / 12 h / Heating

2: boron trifluoride etherate / CH₂Cl₂ / 4 h / -78 °C

With boron trifluoride diethyl etherate; toluene-4-sulfonic acid; In methanol; dichloromethane;
DOI:10.1021/jo01291a026

Reference yield:

: 150-78-7
1,4-dimethoxybezene

: 72229-48-2
2-[1-(2,5-Dimethoxy-phenyl)-1-methoxy-ethyl]-2-trimethylsilanyloxy-cyclobutanone

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / polyphosphoric acid / 70 - 75 °C

2: 80 percent / p-toluenesulfonic acid / methanol / 12 h / Heating

3: boron trifluoride etherate / CH₂Cl₂ / 4 h / -78 °C

With PPA; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; In methanol; dichloromethane;
DOI:10.1021/jo01291a026