ethyl 1-nitro-2-(p-tolyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

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Chemical Name:ethyl 1-nitro-2-(p-tolyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate
CAS No.:1323921-45-4
Molecular Formula:C₂₂H₂₀N₂O₄
Molecular Weight:376.412
Hs Code.:

Synonyms:ethyl 1-nitro-2-(p-tolyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

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Chemical Property of ethyl 1-nitro-2-(p-tolyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

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Technology Process of ethyl 1-nitro-2-(p-tolyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

There total 2 articles about ethyl 1-nitro-2-(p-tolyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 7559-36-6,5153-68-4
4-methyl-β-nitrostyrene

: 88014-09-9
(3,4-dihydro-1H-isoquinolin-2-yl)-acetic acid ethyl ester

: 1350745-32-2
C₂₂H₁₈N₂O₄

: 1323921-45-4
ethyl 1-nitro-2-(p-tolyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

Guidance literature:: 4-methyl-β-nitrostyrene; (3,4-dihydro-1H-isoquinolin-2-yl)-acetic acid ethyl ester; With tris(2,2'-bipyridine)ruthenium dichloride; oxygen; In acetonitrile; at 20 ℃; for 12h; Irradiation;

With N-Bromosuccinimide; In acetonitrile; at 20 ℃; for 1h;
DOI:10.1002/anie.201102306

Reference yield: 48.0%

: 7559-36-6,5153-68-4
4-methyl-β-nitrostyrene

: 88014-09-9
(3,4-dihydro-1H-isoquinolin-2-yl)-acetic acid ethyl ester

: 1323921-45-4
ethyl 1-nitro-2-(p-tolyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

Guidance literature:: 4-methyl-β-nitrostyrene; (3,4-dihydro-1H-isoquinolin-2-yl)-acetic acid ethyl ester; With tert.-butylhydroperoxide; Rh₂(cap)₄*2CH₃CN; potassium carbonate; In decane; acetonitrile;

With N-Bromosuccinimide; In decane; acetonitrile; for 1h;
DOI:10.1016/j.tetlet.2013.04.004