88014-09-9

Basic information

• Product Name: 2(1H)-Isoquinolineacetic acid, 3,4-dihydro-, ethyl ester
• CAS NO: 88014-09-9
• Molecular Formula: C13H17NO2
• Molecular Weight: 219.283
• Mol File: 88014-09-9.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 2(1H)-Isoquinolineacetic acid, 3,4-dihydro-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Isoquinolineacetic acid, 3,4-dihydro-, ethyl ester(88014-09-9)
• EPA Substance Registry System: 2(1H)-Isoquinolineacetic acid, 3,4-dihydro-, ethyl ester(88014-09-9)

Safety Data

• Hazardous Substances Data: 88014-09-9(Hazardous Substances Data)

Usage

General Description

2(1H)-Isoquinolineacetic acid, 3,4-dihydro-, ethyl ester, also known as Tetrahydroisoquinoline ethyl ester, is a chemical compound with the molecular formula C12H15NO2. It is an ethyl ester of 2(1H)-isoquinolineacetic acid, which is used in the synthesis of pharmaceuticals and agrochemicals. The compound has potential therapeutic applications due to its ability to modulate neurotransmitter systems in the brain. It is also known for its sedative and analgesic properties, making it a potential candidate for the development of new drugs for pain management and neurological disorders. The compound is also a versatile building block in organic synthesis, making it valuable for the production of various derivatives with different chemical and pharmaceutical properties.

Upstream product

• 2744-08-3 decahydroisoquinoline 
• 105-39-5 chloroacetic acid ethyl ester 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 141-78-6 ethyl acetate 
• 623-48-3 ethyl iodoacetae 
• 105-36-2 ethyl bromoacetate 
• 119-65-3 isoquinoline 
• 18010-05-4 2-ethoxycarbonyl-methylisoquinolinium bromide 

Downstream Products

• 731810-79-0 2-(1,2,3,4-tetrahydroisoquinolin-2-yl)acetic acid 
• 1264932-15-1 ethyl 10-(3,5-bis(trifluoromethyl)phenyl)-9,11-dioxo-6,9,10,11-tetrahydro-5H-pyrrolo[3',4':3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate 
• 1264932-08-2 ethyl 9,11-dioxo-10-phenyl-6,9,10,11-tetrahydro-5H-pyrrolo-[3′,4′: 3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate 
• 1264932-16-2 ethyl 10-(4-bromo-3-methoxyphenyl)-9,11-dioxo-6,9,10,11-tetrahydro-5H-pyrrolo[3',4':3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate 
• 1264932-10-6 ethyl 9,11-dioxo-10-(m-tolyl)-6,9,10,11-tetrahydro-5H-pyrrolo[3',4':3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate 
• 1264932-09-3 ethyl 9,11-dioxo-10-(o-tolyl)-6,9,10,11-tetrahydro-5H-pyrrolo[3',4':3,4] pyrrolo[2,1-a]isoquinoline-8-carboxylate 
• 1264932-17-3 ethyl 10-benzyl-9,11-dioxo-6,9,10,11-tetrahydro-5H-pyrrolo-[3′,4′:3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate 
• 1264932-13-9 ethyl 10-(2-fluorophenyl)-9,11-dioxo-6,9,10,11-tetrahydro-5H-pyrrolo[3',4':3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate 
• 1264932-12-8 ethyl 10-(4-methoxyphenyl)-9,11-dioxo-6,9,10,11-tetrahydro-5Hpyrrolo[3′,4′:3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate 
• 1264932-11-7 ethyl 10-(2,6-dimethylphenyl)-9,11-dioxo-6,9,10,11-tetrahydro-5H-pyrrolo[3',4':3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate 
• 1264932-20-8 C₂₃H₂₁BrN₂O₄ 
• 1264932-14-0 ethyl 10-(4-bromophenyl)-9,11-dioxo-6,9,10,11-tetrahydro-5H-pyrrolo[3',4':3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate 
• 1264932-23-1 ethyl 9,14-dioxo-5,6,9,14-tetrahydrobenzo[5,6]isoindolo[1,2-a]isoquinoline-8-carboxylate 
• 1404166-31-9 ethyl 2-phenyl-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate 

Relevant articles and documents

Diethyl Azodicarboxylate-Promoted Oxidative [3 + 2] Cycloaddition for the Synthesis of Pyrrolo[2,1- a]isoquinolines

A novel metal-free protocol for the effective and efficient construction of pyrrolo[2,1-a]isoquinolines via a diethyl azodicarboxylate (DEAD)-promoted oxidative [3 + 2] cycloaddition/aromatization tandem reaction is described. Instead of the reported two-

Diethyl Phosphite Promoted Electrochemical Oxidation of Tetrahydroisoquinolines to 3,4-Dihydroisoquinolin-1(2 H)-ones

A diethyl phosphite mediated electrochemical oxidation strategy for the synthesis of 3,4-dihydroisoquinolin-1(2 H)-ones from tetrahydroisoquinolines under mild conditions has been developed. This protocol provides an environmentally friendly and simple way for the construction of C=O bonds in an undivided cell unit.

Visible-light-induced direct α-C(sp3)-H thiocyanation of tertiary amines

Visible-light-induced, eosin Y catalyzed aerobic oxidative α-C(sp3)-H thiocyanation of tertiary amines is reported. The reaction proceeds through visible-light-induced in situ generation of the iminium ion followed by attack of -SCN nucleophile. This is the first example of visible-light-initiated formation of C(sp3)-S bond employing organo-photoredox catalysis. Mild reaction conditions and use of air and visible light as the greenest and sustainable reagents at room temperature are the salient features of the protocol.