(S)-2-[2-Acetylsulfanylmethyl-3-(4-fluoro-phenyl)-butyrylamino]-propionic acid benzyl ester

Base Information

Chemical Name:(S)-2-[2-Acetylsulfanylmethyl-3-(4-fluoro-phenyl)-butyrylamino]-propionic acid benzyl ester
CAS No.:150881-46-2
Molecular Formula:C₂₃H₂₆FNO₄S
Molecular Weight:431.528
Hs Code.:

Synonyms:(S)-2-[2-Acetylsulfanylmethyl-3-(4-fluoro-phenyl)-butyrylamino]-propionic acid benzyl ester

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Chemical Property of (S)-2-[2-Acetylsulfanylmethyl-3-(4-fluoro-phenyl)-butyrylamino]-propionic acid benzyl ester

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Technology Process of (S)-2-[2-Acetylsulfanylmethyl-3-(4-fluoro-phenyl)-butyrylamino]-propionic acid benzyl ester

There total 6 articles about (S)-2-[2-Acetylsulfanylmethyl-3-(4-fluoro-phenyl)-butyrylamino]-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 5557-81-3,5557-83-5,34404-37-0
L-alanine benzyl ester hydrochloride

: 150881-66-6
2-acetylthiomethyl-3-[(4-fluoro)phenyl]butanoic acid

: 150881-46-2
(S)-2-[2-Acetylsulfanylmethyl-3-(4-fluoro-phenyl)-butyrylamino]-propionic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; Ambient temperature;
DOI:10.1021/jm00034a005

Reference yield:

: 65130-46-3
1-(4-fluorophenyl)ethyl bromide

: 150881-46-2
(S)-2-[2-Acetylsulfanylmethyl-3-(4-fluoro-phenyl)-butyrylamino]-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) EtONa / 1.) EtOH, 0 deg C, 15 min, 2.) EtOH, 40 deg C, overnight

2: 89 percent / KOH / ethanol / 0 - 20 °C

3: Et₂NH / H₂O / 48 h / Ambient temperature

4: aq. NaOH / acetone / 0 - 20 °C

5: 100 percent / CH₂Cl₂ / 48 h / 40 - 80 °C

6: 62 percent / Et₃N, 1-hydroxybenzotriazole, DCC / tetrahydrofuran; CH₂Cl₂ / Ambient temperature

With potassium hydroxide; sodium hydroxide; sodium ethanolate; benzotriazol-1-ol; diethylamine; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; dichloromethane; water; acetone;
DOI:10.1021/jm00034a005

Reference yield:

: 155943-75-2
3-(4-Fluoro-phenyl)-2-methylene-butyric acid

: 150881-46-2
(S)-2-[2-Acetylsulfanylmethyl-3-(4-fluoro-phenyl)-butyrylamino]-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / CH₂Cl₂ / 48 h / 40 - 80 °C

2: 62 percent / Et₃N, 1-hydroxybenzotriazole, DCC / tetrahydrofuran; CH₂Cl₂ / Ambient temperature

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00034a005