65130-46-3

Basic information

• Product Name: 1-(2-BROMOETHYL)-4-FLUOROBENZENE
• Synonyms: 4-FLUOROPHENETHYL BROMIDE;4-FLUORO-1-(2-BROMOETHYL)BENZENE;1-FLUORO-4-(2-BROMOETHYL)BENZENE;2-(4-FLUOROPHENYL)ETHYL BROMIDE;1-BROMO-2-(4-FLUOROPHENYL)ETHANE;1-(2-BROMOETHYL)-4-FLUOROBENZENE;1-(2-Bromomethyl)-4-fluorobenzene;1-(1-Bromoethyl)-4-fluorobenzene
• CAS NO: 65130-46-3
• Molecular Formula: C₈H₈BrF
• Molecular Weight: 203.05
• Product Categories: Fluorine series
• Mol File: 65130-46-3.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 100-104 °C15 mm Hg(lit.)
• Flash Point: 200 °F
• Appearance: /
• Density: 1.4498 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.534(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 1-(2-BROMOETHYL)-4-FLUOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-BROMOETHYL)-4-FLUOROBENZENE(65130-46-3)
• EPA Substance Registry System: 1-(2-BROMOETHYL)-4-FLUOROBENZENE(65130-46-3)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-51/53
• Safety Statements: 61
• WGK Germany: 2
• Hazardous Substances Data: 65130-46-3(Hazardous Substances Data)

Usage

General Description

1-(2-Bromoethyl)-4-fluorobenzene is a chemical compound with the molecular formula C8H8BrF. As suggested by its name, this compound consists of a benzene ring that is substituted with a fluorine atom (Fluoro-) and a 2-Bromoethyl group. The term "1-(2-Bromoethyl)" refers to the position and type of the alkyl group attached to the benzene ring. This means that the bromoethyl group is attached to the first carbon atom of the benzene ring while the fluorine atoms are on the fourth carbon atom. It's often used as a reagent or building block in organic synthesis to create more complex molecules. Properties such as the boiling point, melting point, and specific gravity of this chemical vary depending on the conditions under which it's stored and used. Safety information is essential when handling substances like this as it may present hazard and risks for health and surroundings.

Upstream product

• 462-06-6 fluorobenzene 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 459-47-2 1-ethyl-4-fluorobenzene 
• 405-99-2 para-fluorostyrene 
• 52780-14-0 1-(3-bromophenyl)ethanol 
• 403-41-8 1-(4-Fluorophenyl)ethanol 

Downstream Products

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 1115389-44-0 C₁₅H₁₁FN₂O₂ 
• 862270-46-0 4-[(1S,1R)-1-(4-fluorophenyl)ethyl]piperazine-1-carboxylic acid tert-butyl ester 
• 1450652-63-7 N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-(1-(4-fluorophenyl)ethyl)-2-methyl-1H-indole-3-carboxamide 
• 75908-73-5 (+/-)-2-(4-flurophenyl)propanoic acid 
• 672293-90-2 1R-[1-(4-fluoro-phenyl)-ethyl]-3R-methyl-piperazine 

Relevant articles and documents

NOVEL TETRAZOLE COMPOUNDS AND THEIR USE IN THE TREATMENT OF TUBERCULOSIS

The invention relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof and their use in therapy, for example in the treatment of mycobacterial infections or in the treatment of diseases caused by mycobacterium, such as tuberculosis.

Transition-Metal-Free Stereospecific Cross-Coupling with Alkenylboronic Acids as Nucleophiles

We herein report a transition-metal-free cross-coupling between secondary alkyl halides/mesylates and aryl/alkenylboronic acid, providing expedited access to a series of nonchiral/chiral coupling products in moderate to good yields. Stereospecific SN2-type coupling is developed for the first time with alkenylboronic acids as pure nucleophiles, offering an attractive alternative to the stereospecific transition-metal-catalyzed C(sp2)-C(sp3) cross-coupling.

Scalable anti-Markovnikov hydrobromination of aliphatic and aromatic olefins

To improve access to a key synthetic intermediate we targeted a direct hydrobromination-Negishi route. Unsurprisingly, the anti-Markovnikov addition of HBr to estragole in the presence of AIBN proved successful. However, even in the absence of an added initiator, anti-Markovnikov addition was observed. Re-examination of early reports revealed that selective Markovnikov addition, often simply termed "normal" addition, is not always observed with HBr unless air is excluded, leading to the rediscovery of a reproducible and scalable initiator-free protocol.