trans-(1S,3S)-6,7-dimethoxy-1-(4-trifluoromethylphenyl)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:trans-(1S,3S)-6,7-dimethoxy-1-(4-trifluoromethylphenyl)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:1433219-45-4
Molecular Formula:C₁₉H₂₀F₃NO₃
Molecular Weight:367.368
Hs Code.:

Synonyms:trans-(1S,3S)-6,7-dimethoxy-1-(4-trifluoromethylphenyl)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of trans-(1S,3S)-6,7-dimethoxy-1-(4-trifluoromethylphenyl)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline

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Technology Process of trans-(1S,3S)-6,7-dimethoxy-1-(4-trifluoromethylphenyl)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline

There total 3 articles about trans-(1S,3S)-6,7-dimethoxy-1-(4-trifluoromethylphenyl)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.5%

: 1433219-49-8
methyl trans-(1S,3S)-6,7-dimethoxy-1-(4-trifluoromethylphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

: 1433219-45-4
trans-(1S,3S)-6,7-dimethoxy-1-(4-trifluoromethylphenyl)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1002/chem.201202615

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 1433219-45-4
trans-(1S,3S)-6,7-dimethoxy-1-(4-trifluoromethylphenyl)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 0 - 20 °C / Molecular sieve; Inert atmosphere

1.2: Reflux; Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

With lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane; 1.1: |Pictet-Spengler Synthesis;
DOI:10.1002/chem.201202615

Reference yield:

: 78083-80-4
(S)-2-amino-3-(3,4-dimethoxyphenyl)propionic acid methyl ester

: 1433219-45-4
trans-(1S,3S)-6,7-dimethoxy-1-(4-trifluoromethylphenyl)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 0 - 20 °C / Molecular sieve; Inert atmosphere

1.2: Reflux; Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

With lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane; 1.1: |Pictet-Spengler Synthesis;
DOI:10.1002/chem.201202615