C₁₂H₁₆O₃

Base Information

• Chemical Name: C₁₂H₁₆O₃
• CAS No.: 1431854-78-2
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.257
• Mol file: 1431854-78-2.mol

Synonyms:C₁₂H₁₆O₃

Chemical Property of C₁₂H₁₆O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₆O₃

There total 5 articles about C₁₂H₁₆O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(S)-4-Oxo-3-phenyl-butyric acid ethyl ester → C12H16O3 (1431854-78-2)

Guidance literature:

With sodium cyanoborohydride; In acetic acid; ethyl acetate; at 20 ℃; for 0.333333h;

DOI:10.1016/j.tetasy.2013.02.016

Reference yield:

3-Phenylpropenol (104-54-1) → C12H16O3 (1431854-78-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hexanoic acid / 17 h / 166 °C / Heating

2.1: potassium hydroxide / water; methanol / 1 h / Inert atmosphere; Reflux

3.1: Pseudomonas cepacia lipase / 24 h / 40 °C / Enzymatic reaction

4.1: ozone / dichloromethane / -78 °C

4.2: 0.5 h / -10 °C

5.1: sodium cyanoborohydride / ethyl acetate; acetic acid / 0.33 h / 20 °C

With Pseudomonas cepacia lipase; sodium cyanoborohydride; ozone; hexanoic acid; potassium hydroxide; In methanol; dichloromethane; water; acetic acid; ethyl acetate; 1.1: |Claisen Condensation;

DOI:10.1016/j.tetasy.2013.02.016

Reference yield:

3-phenylpent-4-enoic acid (5703-57-1,132032-89-4) → C12H16O3 (1431854-78-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: penicillium roqueforti lipase / toluene / 24 h / 40 °C / Inert atmosphere; Enzymatic reaction

2.1: ozone / dichloromethane / -78 °C

2.2: 0.5 h / -10 °C

3.1: sodium cyanoborohydride / ethyl acetate; acetic acid / 0.33 h / 20 °C

With penicillium roqueforti lipase; sodium cyanoborohydride; ozone; In dichloromethane; acetic acid; ethyl acetate; toluene;

DOI:10.1016/j.tetasy.2013.02.016

upstream raw materials:

3-Phenylpropenol

(R)-(+)-3-phenyl-4-pentenoic acid ethyl ester

3-phenylpent-4-enoic acid

ethyl 3-phenyl-4-pentenoate

Downstream raw materials:

C₁₃H₁₈O₅S

(S)-4-phenyl-1-tosylpyrrolidin-2-one

C₁₂H₁₇NO₂

4-amino-(3S)-3-phenyl-butyric acid hydrochloride